Back to the articles list | Back to browse issues page

Ethics code: IR.ABADANUMS.REC. 1399.186

XML Print

Evaluation of Diagnostic Markers in Neurological Patients with COVID-19
Tina Eghdampanah Foumani , Naser Kamyari , Mohammad Mehdi Shadrvan , Fatemeh Khishvand , Fatemeh Shahroud Dezful , Khadijeh Kanani , Atefeh Zahedi , Sara Mobarak , Esmat Radmanesh *
Department of Physiology, Abadan University of Medical Sciences, Abadan, Iran
Abstract:   (196 Views)
Introduction: The interaction between COVID-19 and pre-existing neurological diseases remains poorly understood, highlighting the need to identify key prognostic markers. This study aimed to characterize the clinical and laboratory profiles and identify predictors of peripheral oxygen saturation (SpO₂) in hospitalized patients with pre-existing neurological disorders and COVID-19. Methods: This retrospective cross-sectional study included 128 hospitalized COVID-19 patients with neurological diseases at Taleghani Educational Hospital in Abadan, Iran, from March 2020 to March 2022. Demographic, clinical, and laboratory data were extracted from the Hospital Information System and patient files. Results: On average, patients exhibited elevated levels of key laboratory markers, including renal (creatinine, BUN), hepatic (ALP, direct bilirubin, AST, ALT), coagulation (PT, aPTT, INR), and inflammatory (ESR) indicators. The mean peripheral oxygen saturation (SpO₂) was below the normal range (91.71 ± 7.88%). Multivariable linear regression revealed that in-hospital mortality (B = −5.93; P < 0.001), increased respiratory rate (B = -0.10 per breath/min; P = 0.03), and intubation (B = −5.58; P < 0.001) were significantly associated with lower SpO₂ levels. Conclusion: In this cohort of neurological patients with COVID-19, dysregulation of renal, hepatic, and coagulation markers was common. Critically, hypoxemia (lower SpO₂) was strongly associated with adverse outcomes, including mortality, respiratory distress, and the need for mechanical ventilation. These findings underscore the importance of monitoring these specific biomarkers and SpO₂ to improve risk stratification and guide clinical management in this high-risk patient population.
 
Keywords: Biomarkers, Coagulation markers, COVID-19, Liver markers, Neurological disorders, Renal markers, SpO₂
     
Type of Study: Original article | Subject: Other
Received: 2025/07/17 | Accepted: 2026/03/10
Add your comments about this article : Your username or Email:
CAPTCHA
Send email to the article author

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.