Department of Microbiology, Chengalpattu Medical College, Chengalpattu, Tamil Nadu, India
Abstract: (6 Views)
Introduction: Fungal infections are an emerging threat in immunocompromised individuals. Among the causative agents, Fusarium solani, a filamentous mold, is a notable opportunistic pathogen. F. solani infections are associated with significant morbidity and mortality, largely due to the organism's aggressive nature and broad intrinsic resistance to a wide range of antifungal agents, particularly certain azoles (e.g., fluconazole, itraconazole) and echinocandins. Case presentations: This report describes three distinct cases of F. solani infection with varied clinical manifestations. The first case involved a 67-year-old male farmer who developed fungal keratitis following ocular trauma; corneal scraping cultures grew F. solani. The second case involved a 55-year-old patient with a history of chronic obstructive pulmonary disease (COPD) who presented with an acute exacerbation. A computed tomography (CT) scan of the chest revealed a small area of consolidation, and sputum culture identified F. solani as the causative pathogen. The third case involved a 57-year-old patient with a history of alcoholic liver disease who developed progressive respiratory failure requiring mechanical ventilation. The patient showed no clinical improvement with broad-spectrum antibiotic therapy. Subsequent blood cultures confirmed fungemia, yielding F. solani. Conclusion: These cases underscore the diverse clinical presentations of F. solani, particularly in immunocompromised individuals, and demonstrate that favorable outcomes are achievable with timely recognition and appropriate antifungal therapy. Early clinical suspicion and prompt mycological confirmation are essential, especially when patients fail to respond to empirical antibacterial treatment.
Keywords: Fungal keratitis, Fungemia, Fusariosis, Fusarium solani, Immunocompromised host, Pulmonary fusariosis
Type of Study: Case Report |
Subject:
Microbial pathogenesis
Received: 2025/07/10 | Accepted: 2026/02/21
Received: 2025/07/10 | Accepted: 2026/02/21
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