en Microbial pathogenesis Microbial pathogenesis Case Report Case Report <div style="text-align: justify;"><span style="font-size:12pt"><span style="line-height:150%"><span calibri="" style="font-family:"><b><span new="" roman="" style="font-family:" times="">Introduction:</span></b><span new="" roman="" style="font-family:" times=""> Fungal infections are an emerging threat in immunocompromised individuals. Among the causative agents, <i>Fusarium solani</i>, a filamentous mold, is a notable opportunistic pathogen. <i>F. solani</i> infections are associated with significant morbidity and mortality, largely due to the organism&#39;s aggressive nature and broad intrinsic resistance to a wide range of antifungal agents, particularly certain azoles (<i>e.g</i>., fluconazole, itraconazole) and echinocandins. <b>Case presentations:</b> This report describes three distinct cases of <i>F. solani</i> infection with varied clinical manifestations. The first case involved a 67-year-old male farmer who developed fungal keratitis following ocular trauma; corneal scraping cultures grew <i>F. solani</i>. The second case involved a 55-year-old patient with a history of chronic obstructive pulmonary disease (COPD) who presented with an acute exacerbation. A computed tomography (CT) scan of the chest revealed a small area<b> </b>of consolidation, and sputum culture identified <i>F. solani</i> as the causative pathogen. The third case involved a 57-year-old patient with a history of alcoholic liver disease who developed progressive respiratory failure requiring mechanical ventilation. The patient showed no clinical improvement with broad-spectrum antibiotic therapy. Subsequent blood cultures confirmed fungemia, yielding<b> </b><i>F. solani</i>. <b>Conclusion:</b> These cases underscore the diverse clinical presentations of <i>F. solani</i>, particularly in immunocompromised individuals, and demonstrate that favorable outcomes are achievable with timely recognition and appropriate antifungal therapy. Early clinical suspicion and prompt mycological confirmation are essential, especially when patients fail to respond to empirical antibacterial treatment. </span></span></span></span></div> <br> &nbsp; Fungal keratitis, Fungemia, Fusariosis, Fusarium solani, Immunocompromised host, Pulmonary fusariosis 0 0 http://jommid.pasteur.ac.ir/browse.php?a_code=A-10-665-1&slc_lang=en&sid=1 Abhinaya Thennarasu abhinayat1995@gmail.com 0009-0006-5545-2866 Yes Department of Microbiology, Chengalpattu Medical College, Chengalpattu, Tamil Nadu, India Nishana Murugan 0009-0008-3985-3832 No Department of Microbiology, Chengalpattu Medical College, Chengalpattu, Tamil Nadu, India Aruna Arumugam Samynathan 0000-0002-3469-4456 No Department of Microbiology, Chengalpattu Medical College, Chengalpattu, Tamil Nadu, India