Pasteur Institute of Iran
Journal of Medical Microbiology and Infectious Diseases
Wed, Aug 13, 2025
Volume 13, Issue 2 (6-2025)
JoMMID 2025, 13(2): 156-162 |
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Salehi-Vaziri M, Jalali T, Bolandakhtar A A, Fazlalipour M, Mostafavi E, Eybpoosh S, et al . Suspected Crimean-Congo Haemorrhagic Fever Re-Infection: A Case Report with Atypical Serological Profile. JoMMID 2025; 13 (2) :156-162
URL: http://jommid.pasteur.ac.ir/article-1-767-en.html
URL: http://jommid.pasteur.ac.ir/article-1-767-en.html
Mostafa Salehi-Vaziri 
, Tahmineh Jalali , Ali Asghar Bolandakhtar , Mehdi Fazlalipour , Ehsan Mostafavi , Sana Eybpoosh , Vahid Baniasadi , Mahsa Tavakoli , Tahereh Mohammadi , Sanam Azad-Manjiri , Motahareh Hosseini , Zahra Fereydouni , Mohammad Mehdi Gouya , Gary P Kobinger , Mohammad Hassan Pouriayevali *
, Tahmineh Jalali , Ali Asghar Bolandakhtar , Mehdi Fazlalipour , Ehsan Mostafavi , Sana Eybpoosh , Vahid Baniasadi , Mahsa Tavakoli , Tahereh Mohammadi , Sanam Azad-Manjiri , Motahareh Hosseini , Zahra Fereydouni , Mohammad Mehdi Gouya , Gary P Kobinger , Mohammad Hassan Pouriayevali *
Department of Arboviruses and Viral Hemorrhagic Fevers (National Reference Laboratory), Pasteur Institute of Iran, Tehran, Iran; Research Center for Emerging and Reemerging Infectious Disease, Pasteur Institute of Iran, Tehran, Iran
Abstract: (83 Views)
A 53-year-old male farmer presented with clinical manifestations consistent with Crimean-Congo Hemorrhagic Fever (CCHF) virus infection, reporting a recent history of tick bite. To confirm the diagnosis, molecular and serological assays were performed on four specimens collected following the onset of illness. Reverse transcription-polymerase chain reaction (RT-PCR) detected CCHF virus RNA in the initial sample, while serum immunoglobulin M (IgM) antibodies were undetectable in all specimens. Notably, a robust immunoglobulin G (IgG) antibody response was observed across all samples. The concurrence of detectable viral RNA with the presence of IgG antibodies, but the absence of IgM, in the acute phase sample suggests a potential case of CCHF virus re-infection. These findings hold significant implications for public health, particularly regarding our understanding of CCHF virus infection dynamics, diagnostics, and vaccine development strategies.
Type of Study: Case Report |
Subject:
Infectious diseases and public health
Received: 2025/08/10 | Accepted: 2025/06/11 | Published: 2025/06/11
Received: 2025/08/10 | Accepted: 2025/06/11 | Published: 2025/06/11
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