Volume 13, Issue 2 (6-2025)                   JoMMID 2025, 13(2): 0-0 | Back to browse issues page

XML Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Khan R, Zahoor D, Farhana A, Jehan M. Clinical Characteristics, Breakthrough Infections, and Reinfections with SARS-CoV-2 among Healthcare Workers in the Omicron Wave. JoMMID 2025; 13 (2)
URL: http://jommid.pasteur.ac.ir/article-1-686-en.html
Clinical Characteristics, Breakthrough Infections, and Reinfections with SARS-CoV-2 among Healthcare Workers in the Omicron Wave
Reyaz Khan * , Danish Zahoor , Anjum Farhana , Masarat Jehan
Department of Microbiology, Government Medical College, Srinagar, Jammu & Kashmir, India
Abstract:   (54 Views)
Introduction: A global increase in infections was noted with the emergence of the Omicron variant, which exhibited immune evasion capabilities against previous infections or vaccinations. Healthcare workers (HCWs) faced increased risk from occupational exposure. This study aimed to investigate the clinical characteristics, reinfection rates, and breakthrough infections among HCWs during the Omicron wave. Methods:  A total of 312 HCWs who tested positive for SARS-CoV-2 during the Omicron wave (January 1–February 22, 2022) were enrolled in the study after providing consent. Participating HCWs completed a questionnaire to provide details on demographics, symptoms at testing, comorbidities, vaccination status, and prior COVID-19 infection history. Clinical outcomes were also recorded. Cases of reinfection and breakthrough infection were identified. Results: The median age of HCWs in the study was 32.9 years. The frequency of infection was higher in females (56.7%) and among the professional categories, doctors (58.3%) accounted for the majority of cases. Symptomatic infection was prevalent in 89.7% of cases, with most being mild. Out of 312 healthcare workers, 265 (84.9%) received at least one dose of the Covishield vaccine. Of these, 206 (77.7%) received two doses, and 41 (15.5% of vaccinated HCWs) also received a booster dose. 153 (49.1%) had a history of prior SARS-CoV-2 infection. Hospitalization was required for three unvaccinated HCWs with comorbidities, while no vaccinated HCWs required hospitalization; no deaths occurred. Conclusions: The study found that 312 healthcare workers were infected during the Omicron wave. Vaccination and prior infection did not provide complete protection against the Omicron variant. Consequently, breakthrough infections and reinfections were observed with notable frequency during this period.

 
Keywords: Omicron variant, Reinfection, Breakthrough infection, Covishield vaccination, Healthcare workers
     
Type of Study: Original article | Subject: Other
Received: 2024/09/27 | Accepted: 2025/06/11 | Published: 2025/06/11
Add your comments about this article : Your username or Email:
CAPTCHA
Send email to the article author

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.