Volume 13, Issue 2 (6-2025)                   JoMMID 2025, 13(2): 134-138 | Back to browse issues page

XML Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Patil D P, Dravid M, Ahire K, Bothikar S, Shah F. Burkholderia gladioli Septicemia: A Rare Case Report. JoMMID 2025; 13 (2) :134-138
URL: http://jommid.pasteur.ac.ir/article-1-657-en.html
Burkholderia gladioli Septicemia: A Rare Case Report
Dr Priyanka Patil * , Mrudula Dravid , Karuna Ahire , Subhash Bothikar , Farhan Shah
JMF’s ACPM Medical College, Sakri Road, Morane, Dhule, North Maharashtra, India-424002
Abstract:   (81 Views)
Introduction: Burkholderia gladioli is an emerging opportunistic pathogen in humans. Its phenotypic variability makes identification challenging and can lead to misidentification as other Burkholderia species. Case presentation: We report a case of B. gladioli septicemia in a patient from the North Maharashtra region of India. The isolate was accurately identified using an automated bacterial identification and antimicrobial susceptibility testing system. This case highlights the need for accurate identification for appropriate management of infections caused by uncommon pathogens. Discussion: This case emphasizes the importance of considering B. gladioli in the differential diagnosis, particularly in immunocompromised individuals. Accurate diagnosis and appropriate antimicrobial therapy require a high index of suspicion and advanced identification methods. This report highlights the challenges in identifying B. gladioli and emphasizes the need for increased awareness of its clinical significance and antimicrobial resistance patterns. Conclusion: B. gladioli infections, while uncommon, cause severe disease in human health, particularly in patients with potential immunocompromise or environmental exposures. Improved diagnostic capabilities, such as molecular identification, and increased awareness of B. gladioli's pathogenic potential are essential for effective management of these infections.
Keywords: Burkholderia gladioli, Bacteremia, Opportunistic infection, Bacterial identification
Full-Text [PDF 760 kb]   (13 Downloads)    
Type of Study: Case Report | Subject: Infectious diseases and public health
Received: 2024/03/22 | Accepted: 2025/06/11 | Published: 2025/06/11
References
1. Sastry AS. Essentials of Medical Microbiology. 4th ed. Jaypee Brothers Medical Publishers Pvt Ltd; 2023. p. 534-9.
2. Palleroni NJ, Genus I. Pseudomonas Migula 1894, 237AL. In: Krieg NR, Holt JG, editors. Bergey's manual of systematic bacteriology. Vol. 1. Baltimore: Williams & Wilkins; 1984. p. 141-9.
3. Jiao Z, Kawamura Y, Mishima N, Yang R, Li N, Liu X, et al. Need to differentiate lethal toxin-producing strains of Burkholderia gladioli, which cause severe food poisoning: description of B. gladioli pathovar cocovenenans and an emended description of B. gladioli. Microbiol Immunol. 2003; 47 (12): 915-25. [DOI:10.1111/j.1348-0421.2003.tb03465.x] [PMID]
4. Barker PM, Wood RE, Gilligan PH. Lung infection with Burkholderia gladioli in a child with cystic fibrosis: acute clinical and spirometric deterioration. Pediatr Pulmonol. 1997; 23 (2): 123-5. https://doi.org/10.1002/(SICI)1099-0496(199702)23:2<123::AID-PPUL9>3.0.CO;2-Q [DOI:10.1002/(SICI)1099-0496(199702)23:23.0.CO;2-Q]
5. Christenson JC, Welch DF, Mukwaya G, Muszynski MJ, Weaver RE, Brenner DJ. Recovery of Pseudomonas gladioli from respiratory tract specimens of patients with cystic fibrosis. J Clin Microbiol. 1989; 27 (2): 270-3. [DOI:10.1128/jcm.27.2.270-273.1989] [PMID] [PMCID]
6. Clode FE, Metherell LA, Pitt TL. Nosocomial acquisition of Burkholderia gladioli in patients with cystic fibrosis. Am J Respir Crit Care Med. 1999; 160 (1): 374-5. [DOI:10.1164/ajrccm.160.1.16011] [PMID]
7. Ferroni A, Sermet-Gaudelus I, Abachin E, Quesne G, Lenoir G, Berche P, et al. Use of 16S rRNA gene sequencing for identification of nonfermenting gram-negative bacilli recovered from patients attending a single cystic fibrosis center. J Clin Microbiol. 2002; 40 (10): 3793-7. [DOI:10.1128/JCM.40.10.3793-3797.2002] [PMID] [PMCID]
8. Dobrović K, Mareković I, Payerl-Pal M, Andrijašević N, Škrobo T, Košćak V, et al.. Outbreak of healthcare-associated bacteremia caused by Burkholderia gladioli due to contaminated multidose vials with saline solutions in three Croatian hospitals. Int J Infect Dis. 2022; 121: 152-6 [DOI:10.1016/j.ijid.2022.05.012] [PMID]
9. Khan SU, Gordon SM, Stillwell PC, Kirby TJ, Arroliga AC. Empyema and bloodstream infection caused by Burkholderia gladioli in a patient with cystic fibrosis after lung transplantation. Pediatr Infect Dis J. 1996; 15 (7): 637-9. [DOI:10.1097/00006454-199607000-00020] [PMID]
10. Graves M, Robin T, Chipman AM, Wong J, Khashe S, Janda JM. Four additional cases of Burkholderia gladioli infection with microbiological correlates and review. Clin Infect Dis. 1997; 25 (4): 838-42. [DOI:10.1086/515551] [PMID]
11. Landry ML, Jorgensen JH, Carroll KC, Pfaller MA, Warnock DW, Richter SS, et al. Manual of clinical microbiology. 11th ed. Washington, DC: ASM Press; 2015. [DOI:10.1128/9781555817381]
12. Kennedy MP, Coakley RD, Donaldson SH, Aris RM, Hohneker K, Wedd JP, et al. Burkholderia gladioli: five year experience in a cystic fibrosis and lung transplantation center. J Cyst Fibros. 2007; 6 (4): 267-73. [DOI:10.1016/j.jcf.2006.10.007] [PMID]
13. Segonds C, Clavel-Batut P, Thouverez M, Grenet D, Coustumier AL, Plésiat P, et al. Microbiological and epidemiological features of clinical respiratory isolates of Burkholderia gladioli. J Clin Microbiol. 2009; 47 (5): 1510-6. [DOI:10.1128/JCM.02489-08] [PMID] [PMCID]
14. Boyanton Jr BL, Noroski LM, Reddy H, Dishop MK, Hicks MJ, Versalovic J, et al. Burkholderia gladioli osteomyelitis in association with chronic granulomatous disease: case report and review. Pediatr Infect Dis J. 2005; 24 (9): 837-9. [DOI:10.1097/01.inf.0000177285.44374.dc] [PMID]
15. Imataki O, Kita N, Nakayama-Imaohji H, Kida JI, Kuwahara T, Uemura M. Bronchiolitis and bacteraemia caused by Burkholderia gladioli in a non-lung transplantation patient. New Microbes New Infect. 2014; 2 (6): 175-6. [DOI:10.1002/nmi2.64] [PMID] [PMCID]
16. Hoare S, Cant AJ. Chronic granulomatous disease presenting as severe sepsis due to Burkholderia gladioli. Clin Infect Dis. 1996; 23 (2): 411. [DOI:10.1093/clinids/23.2.411] [PMID]
17. Shin JH, Kim SH, Shin MG, Suh SP, Ryang DW, Jeong MH. Bacteremia due to Burkholderia gladioli: case report. Clin Infect Dis. 1997; 25 (5): 1264-5. [DOI:10.1086/516973] [PMID]
18. Ross JP, Holland SM, Gill VJ, DeCarlo ES, Gallin GI. Severe Burkholderia (Pseudomonas) gladioli infection in chronic granulomatous disease: report of two successfully treated cases. Clin Infect Dis. 1995; 21 (5): 1291-3. [DOI:10.1093/clinids/21.5.1291] [PMID]
19. Dursun A, Zenciroglu A, Karagol BS, Hakan N, Okumus N, Gol N, et al. Burkholderia gladioli sepsis in newborns. Eur J Pediatr. 2012; 171 (10): 1503-9. [DOI:10.1007/s00431-012-1756-y] [PMID]
20. Avgeri SG, Matthaiou DK, Dimopoulos G, Grammatikos AP, Falagas ME. Therapeutic options for Burkholderia cepacia infections beyond co-trimoxazole: a systematic review of the clinical evidence. Int J Antimicrob Agents. 2009; 33 (5): 394-404. [DOI:10.1016/j.ijantimicag.2008.09.010] [PMID]
Add your comments about this article : Your username or Email:
CAPTCHA
Send email to the article author

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.