Volume 11, Issue 4 (12-2023)                   JoMMID 2023, 11(4): 192-199 | Back to browse issues page

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Mashayekh N, Modiri L, Ghane M, Erfani Y. Antimicrobial Effect of Zinc Oxide Nanoparticles against Multidrug-Resistant Acinetobacter baumannii. JoMMID 2023; 11 (4) :192-199
URL: http://jommid.pasteur.ac.ir/article-1-616-en.html
Antimicrobial Effect of Zinc Oxide Nanoparticles against Multidrug-Resistant Acinetobacter baumannii
Nader Mashayekh , Leila Modiri * , Masood Ghane , Yousef Erfani
Department of Microbiology, Faculty of Basic Sciences, Lahijan Branch, Islamic Azad University, Lahijan, Iran
Abstract:   (939 Views)
Introduction: Increased multidrug-resistant (MDR) Acinetobacter baumannii infections pose a significant challenge in hospital settings. Enhanced resistance to antibiotics like fluoroquinolones and β-lactams necessitates adopting alternative treatment strategies such as metal oxide nanoparticles. This study investigated the synergistic effect of zinc oxide nanoparticles (ZnO-NPs) on ciprofloxacin and ceftazidime activity against MDR A. baumannii. Methods: We examined 30 MDR A. baumannii isolates from intensive care unit (ICU) patients in Iran. ZnO-NPs were synthesized via the solvothermal method and characterized using X-ray diffraction (XRD) and field emission scanning electron microscopy (FESEM) to ascertain their crystalline structure and morphology. Antibacterial activity was evaluated by determining minimum inhibitory concentrations (MICs) and inhibition zones through broth microdilution and disk diffusion methods, using concentrations of ciprofloxacin and ceftazidime in combination with ZnO-NPs. Results: ZnO-NPs combined with ciprofloxacin 8 μg/mL and ceftazidime 32 μg/mL exhibited inhibition growth percentage (GI%) increases of 44.9% and 31.65%.  Conclusion: The enhanced in vitro antibacterial effects of combined ZnO-NPs and antibiotics against MDR A. baumannii indicate a synergy. Considering the limited number of isolates, comprehensive research incorporating in vivo models and clinical trials is warranted to evaluate the practicality of this approach in overcoming antibiotic resistance.

 
Keywords: Acinetobacter baumannii, Zinc oxide nanoparticles, Ciprofloxacin, Ceftazidime
Full-Text [PDF 1070 kb]   (309 Downloads)    
Type of Study: Original article | Subject: Anti-microbial agents, resistance and treatment protocols
Received: 2023/11/1 | Accepted: 2023/12/10 | Published: 2024/02/24
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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.