Volume 11, Issue 1 (3-2023)                   JoMMID 2023, 11(1): 60-61 | Back to browse issues page


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Abdul Samad S, Kallarakkal H, Basheer N. Intraventricular Administration of Cefepime for the Treatment of Meningitis due to Pseudomonas aeruginosa. JoMMID 2023; 11 (1) :60-61
URL: http://jommid.pasteur.ac.ir/article-1-515-en.html
Department of Infectious Diseases, Aster Malabar Institute of Medical Sciences, Calicut, India
Abstract:   (851 Views)
Beta-lactam antibiotics are traditionally not considered for intrathecal therapy, despite their poor penetration into the cerebrospinal fluid (CSF) during intravenous therapy, because target concentrations of the beta-lactam antibiotic in the central nervous system can usually be achieved with a higher intravenous dose [1]. However, in cases where inadequate clinical response is seen even with maximal doses of intravenous antibiotics, and when access for intraventricular administration of antibiotics is available, this route can be utilized for patient management, as we report now. Cefepime at high doses has been reported to cause seizures and encephalopathy [2]. However, therapeutic intraventricular administration of cefepime for the management of nosocomial meningitis, leading to successful microbiological clearance has not been reported previously in the literature.
Full-Text [PDF 418 kb]   (355 Downloads)    
Type of Study: Letter to the Editor | Subject: Anti-microbial agents, resistance and treatment protocols
Received: 2022/12/14 | Accepted: 2023/02/28 | Published: 2023/05/20

References
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2. Reza M, Bagert B, Reese G, Reeves MA. Cefepime-induced Neurotoxicity in the Critically Ill: A Modifiable Risk Factor (P7-12.001). Neurology. 2022; 98 (18 Supplement).
3. Pacifici GM, Marchini G. Clinical Pharmacology of Cefepime in Infants and Children. Int J Pediatr. 2017; 5 (4): 4723-40.
4. Durand-Maugard C, Lemaire-Hurtel AS, Gras-Champel V, Hary L, Maizel J, Prud'homme-Bernardy A, et al. Blood and CSF monitoring of cefepime-induced neurotoxicity: nine case reports. J Antimicrob Chemother. 2012; 67 (5): 1297-9. [DOI:10.1093/jac/dks012]
5. Payne LE, Gagnon DJ, Riker RR, Seder DB, Glisic EK, Morris JG, et al. Cefepime-induced neurotoxicity: a systematic review. Crit Care. 2017; 21 (1): 276. [DOI:10.1186/s13054-017-1856-1]

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Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.