Volume 10, Issue 2 (6-2022)                   JoMMID 2022, 10(2): 75-79 | Back to browse issues page

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Mousavi M, Mousavi N, Ahmadi S A Y, Kaviani M. Investigating Two-stage Tuberculin Skin Test for Screening Latent Tuberculosis Infections in Diabetic Patients: A Regional Study in Khorramabad, Iran. JoMMID 2022; 10 (2) :75-79
URL: http://jommid.pasteur.ac.ir/article-1-406-en.html
Investigating Two-stage Tuberculin Skin Test for Screening Latent Tuberculosis Infections in Diabetic Patients: A Regional Study in Khorramabad, Iran
Mahshad Mousavi , Nazanin Mousavi , Seyyed Amir Yasin Ahmadi , Mozhgan Kaviani
Department of Internal Medicine, School of Medicine, Lorestan University of Medical Science, Khorramabad, Iran
Abstract:   (1095 Views)
Introduction: latent tuberculosis infections (LTBI) are not detectable by a single-stage tuberculin test and maybe detected after repeating tests 7-21 days later. This phenomenon, called the boosting phenomenon, supports a two-stage test to identify false negatives in a single-stage test. The present study investigates the value of a two-stage tuberculin test in diabetic patients. Methods: We performed a tuberculin test for 195 diabetic patients. The patients with induration > 10 mm were subjected to a second tuberculin test 7-21 days later. Results: Of 195 patients, 115 came for measuring the tuberculin test induration, which was positive in 3 out of 115 patients (2.61%). Of the remaining 112 patients, 53 patients were subjected to the second test, and 38 patients came back for measuring the induration, which became positive in 4 (10.52%) patients. Conclusion: The increased LTBI rate from 2.61% to 10.52% following the second tuberculin test indicates a boosting phenomenon due to a delayed hypersensitivity reaction. Hence, patients with latent tuberculosis who had a false negative test in the first stage were identified.
 
Keywords: Tuberculosis, Latent tuberculosis, Type 2 diabetes mellitus, Two-stage tuberculin test, Boosting phenomenon
Full-Text [PDF 671 kb]   (542 Downloads)    
Type of Study: Original article | Subject: Diagnostic/screening methods and protocols
Received: 2021/10/9 | Accepted: 2022/06/11 | Published: 2022/06/8
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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.