Volume 11, Issue 3 (9-2023)                   JoMMID 2023, 11(3): 168-173 | Back to browse issues page

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Sourazur G. Evaluating Vitamin C Vaginal Tablets Effect on Gardnerella vaginalis Infection. JoMMID 2023; 11 (3) :168-173
URL: http://jommid.pasteur.ac.ir/article-1-391-en.html
بیمارستان علوی اردبیل
Abstract:   (356 Views)
Introduction: Bacterial vaginosis (BV) is the most common vaginitis in childbearing women. Despite the availability of various treatments, recurrence rates are high. This study investigated the effects and side effects of vitamin C vaginal tablets in patients with Gardnerella vaginalis infection based on Amsel criteria and the culture. Methods: A double-blind, randomized clinical trial was conducted on 48 non-pregnant women aged 15-40 years referred to Alawi Hospital in Ardabil Province, Iran. After the diagnosis of G. vaginalis infection based on Amsel criteria and culture methods, the patients were randomly assigned to receive either intravaginal 250 mg vitamin C (intervention group, n=24) or 250 mg metronidazole tablets (control group, n=24) for eight nights. The patients were evaluated 10 ± 2 and 30 ± 2 days before and after the treatment. Results: Culture and Amsel criteria showed significant improvement in both groups during the first and fourth weeks of treatment. However, the intervention group that received vitamin C showed a more substantial improvement (P<0.002, P<0.001). Intravaginal vitamin tablets were more effective than metronidazole tablets in treating G. vaginalis infection. Furthermore, vitamin C tablets improved the abnormal growth of vaginal microflora and reduced the abnormally high pH of the vagina. This treatment effectively prevented the recurrence of G. vaginalis infection for one month. Conclusion: Vitamin C vaginal tablets showed to be a promising alternative treatment for G. vaginalis infection, but further research is needed to confirm these findings and address potential limitations.
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Type of Study: Original article | Subject: Microbial pathogenesis
Received: 2021/09/18 | Accepted: 2023/09/10 | Published: 2023/11/11

1. Akbarzadeh Pasha B, Akbarzadeh Pasha H. Obstetrics and Gynecology ORDER. Tehran, Golban Publications, first edition; 2020: 180-628.
2. Forouhesh Tehrani H, Saadat S. Microbiology of diagnosis. Tehran, Abadis Teb Publications, 1st edition; 2020, pp. 160-240.
3. Asghari B,Jenabi Namin M. Henry Davidson Medical Microbiology. McPherson RA, Pincus MR. 1 st ed, Tehran Publisher: ArtinTeb, 2017: 42-168.
4. Jafarnejad F, Nayeban S, Ghazvini K. Diagnostic Value of Amsel's Clinical Criteria for Diagnosis of Bacterial Vaginosis. Iran. J Obstet Gynecol Infertil. 2017; 13 [1]: 33-8.
5. Rajabnia Chenazi. Comprehensive Guide to Pharmacology and Copywriting of Obstetrics and Gynecology, Second Edition, Tehran, 2017:42-117.
6. Hajfoghaha M, Keshaverz T, Parsanejed EM,Rajaee fard A. Use of vitamin C and premature rupture of fetal vessels. Journal of Shiraz University of Medical Sciences. 2009; 3 (1): 33-39.
7. Ondendaal HJ, Choeman J, Steyn PS, Grove D. Preterm labor-- is bacterial vaginosis involved? S Afr Med J. 2002; 92 (3): 231-4.
8. Hon JK. The Effect of Vitamin C on Vaginitis in Pregnancy and in Normal Korean Pregnant Women. Korean J Prinatol. 2006; 17 (1): 62-7.
9. Powell AM, Nyirjest P. New perspectives on the normal vagina and noninfectious causes of discharge. Clin Obstet Gynecol. 2015; 58 (3): 453-63. [DOI:10.1097/GRF.0000000000000124] [PMID]
10. Larsson P, Stray-Pedersen B, Rytting K, Larsen S. Human lactobacilli as supplementation of clindamycin to patients with bacterial vaginosis reduce the recurrence rate; a 6- month double blind, randomized, placebo- controlled study. BMC Womans Health. 2008; 8 (3): 1-8. [DOI:10.1186/1472-6874-8-3] [PMID] [PMCID]
11. Esfahani A, Omran AN, Salehi Z, Shams-Ghahfarokhi M, Ghane M, Eybpoosh S, Razzaghi-Abyaneh M. Molecular epidemiology, antifungal susceptibility, and ERG11 gene mutation of Candida species isolated from vulvovaginal candidiasis: Comparison between recurrent and non-recurrent infections. Microbial Pathogenesis. 2022: 105696. [DOI:10.1016/j.micpath.2022.105696] [PMID]
12. Allsworth JE, Peipert JF. Prevalence of bacterial vaginosis: 2001- 2004 national health and nutrition examination survey data. Obstet Gynecol. 2007; 109 (1): 114-20. [DOI:10.1097/01.AOG.0000247627.84791.91] [PMID]
13. Hemalatha R, Ramalaxmi BA, Swetha E, Balakrishna N, Mastromarino P. Evaluation of vaginal pH for detection of bacterial vaginosis. Indian J Med Res. 2013; 138 (3): 354-9.
14. Ness RB, Hillier SL, Richter HE, Soper DE, Stamm C, McGregor J, et al. Douching in relation to bacterial vaginosis, lactobacilli, and facultative bacteria in the vagina. Obstet Gynecol. 2002; 100 (4): 765-72. https://doi.org/10.1097/00006250-200210000-00025 [DOI:10.1016/S0029-7844(02)02184-1] [PMID]
15. Petersen E, Genet M, Caserin M, Palmieri R. Efficacy and safety of vitamin c vaginal tablets in the treatment of non specefic vaginitis. Obstetrics & Gynecology. 2011; 61 (4): 260-5.
16. Abbaspo Z, Goodarzi F, Abbaspour MR. Comparison of the effect of vitamin C vaginal pill with metronidazole vaginal gel on the improvement and relapse of bacterial vaginosis. Afr J Pharm Pharmacol. 2010; 4 (7): 484-9.
17. Petersen EE, Magnani P. The efficacy and safety of vaginal pills of vitamin C in the treatment of nonspecific vaginitis. A randomised, double blind, placebo-controlled study. Eur J Obstet Gynecol Reprod Biol. 2004; 117 (1): 70-5. [DOI:10.1016/j.ejogrb.2004.02.032] [PMID]
18. Goodarzi F, Abbaspour Z, Reza Abbaspoor MR, Moomeni E, Zandi KA. The effect of vitamin C vaginal tablets on Amesell Criterion in Patients with Bacterial Vaginosis. Armaghane Danesh. 2011; 16 (4): 372-80.
19. Polatti F. Bacterial vaginosis, atopobium vaginae and nifuratel. Curr Clin Pharmacol. 2012; 7 (1): 36-40. [DOI:10.2174/157488412799218824] [PMID] [PMCID]
20. Krasnopolsky VN, Prilepskaya VN, Polatti F, Zavochentsera NV, Bayramova GR, Caserini M, et al. Efficacy of vitamin C vaginal tablets as prophylaxis for recurrent bacterial vaginosis: a randomised, double-blind, placebocontrolled clinical trial. J Clin Med Res. 2013; 5 (4): 309-15. [DOI:10.4021/jocmr1489w] [PMID] [PMCID]

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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.