Volume 7, Issue 3 (7-2019)                   JoMMID 2019, 7(3): 61-65 | Back to browse issues page

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Seyed N, Rafati S. Resolution and pro-resolving lipid mediators in Leishmania infection. JoMMID 2019; 7 (3) :61-65
URL: http://jommid.pasteur.ac.ir/article-1-195-en.html
Resolution and pro-resolving lipid mediators in Leishmania infection
Negar Seyed , Sima Rafati
Department of Immunotherapy and leishmania vaccine research
Abstract:   (3771 Views)
The acute inflammatory response is the body’s natural reaction to inciting stimuli including trauma and pathogens. Well-known pro-inflammatory metabolites take control of this reaction to recruit the leukocytes into the inflamed tissue. These cells professionally ingest and kill the invading pathogens and clear the debris of dead or injured cells. This further signals the tissue regeneration and gain of function, another active process mediated by newly uncovered metabolites. These newly identified metabolites are anti-inflammatory in nature and downregulate the active inflammation. These molecules and their cognate receptors are novel targets for the treatment of chronic inflammatory diseases. Although not very well understood, these mediators are suspected to support intracellular parasite survival (as Leishmania parasite) and are worth further investigation for innovative therapeutic interventions.
Keywords: Resolution, lipid mediators, Leishmania infection
Full-Text [PDF 395 kb]   (1246 Downloads)    
Type of Study: Review article | Subject: Microbial pathogenesis
Received: 2019/06/15 | Accepted: 2019/06/19 | Published: 2019/11/3
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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.