Journal of Medical Microbiology and Infectious Diseases Journal of Medical Microbiology and Infectious Diseases JoMMID Medical Sciences http://jommid.pasteur.ac.ir 1 admin 2345-5349 2345-5330 8 10.61882/JoMMID 14 8888 13 en jalali 1404 11 1 gregorian 2026 2 1 14 2 online 1 fulltext
en Immune Evasion Mechanisms of Acinetobacter baumannii: A Thematic Review Host-pathogen interactions and susceptibility factors Host-pathogen interactions and susceptibility factors Review article Review article <span style="font-size:11pt"><span style="line-height:200%"><span style="font-family:Calibri,sans-serif"><i><span style="font-size:12.0pt"><span style="line-height:200%"><span new="" roman="" style="font-family:" times="">Acinetobacter baumannii</span></span></span></i><span style="font-size:12.0pt"><span style="line-height:200%"><span new="" roman="" style="font-family:" times=""> is a multidrug-resistant, Gram-negative pathogen known for causing severe healthcare-associated infections. This bacterium effectively evades host immune defenses through multiple strategies. It alters surface components like lipopolysaccharides and capsular polysaccharides to avoid recognition by pattern recognition receptors and resist complement activation. <i>A. baumannii</i> also forms biofilms, secretes virulence factors (e.g., proteases, OMVs), and utilizes a type VI secretion system to enhance survival. The pathogen neutralizes reactive oxygen species via antioxidant enzymes and degrades neutrophil extracellular traps to escape immune clearance. It can survive intracellularly in macrophages and modulates inflammasome activation to suppress host responses. Understanding these mechanisms is critical for designing new therapeutics, including vaccines and immunotherapies, to combat this high-priority pathogen.</span></span></span></span></span></span><br> &nbsp; ,Acinetobacter baumannii,Immune evasion mechanisms,virulence factors,Host Immune Responses,Innate immunity 0 0 http://jommid.pasteur.ac.ir/browse.php?a_code=A-10-666-1&slc_lang=en&sid=1 Hafez Mozayyan Esfahani hafezmozayyan@gmail.com Yes Department of Cell and Molecular Biology & Microbiology, Faculty of Biological Science and Technology, University of Isfahan, Isfahan, Iran. Arefe Nikmehr Arefeniikmehr@gmail.com No Department of Microbiology, Faculty of Basic Sciences, Shahid Ashrafi Esfahani University, Esfahan, Iran. Soodabeh Rostami srostami1876@gmail.com No Infectious Diseases and Tropical Medicine Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.