en Other Other Original article Original article <b><span lang="EN-IN" style="font-size:10.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times="">Introduction:</span></span></span></b><span lang="EN-IN" style="font-size:10.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times=""> This study aimed to determine the seroprevalence of rubella IgG antibodies among women of reproductive age in Mysuru, India. Estimating the rubella seroprevalence in this populationis crucial for informing public health interventions aimed at preventing congenital rubella syndrome (CRS), a severe birth defect caused by rubella infection during pregnancy. <b>Methods:</b> A cross-sectional serosurvey was conducted among women of reproductive age (18&ndash;38 years) in Mysuru city from January 15, 2019, to December 31, 2019. A total of 311 participants were recruited using a convenience sampling technique. Rubella IgG antibody levels were measured using ELISA<b> </b>with the CALBIOTECH Rubella IgG ELISA kit. <b>Results:</b> The mean age of the 311 women of reproductive age included in the study was 25.8 &plusmn; 5.2 years. Age was not significantly associated with rubella IgG antibody status (<i>P</i>=0.123). Overall, 95.5% (n = 297) of participants were seropositive for rubella IgG antibodies, indicating immunity against rubella. The lowest seroprevalence (92.1%, n = 51) was observed in the 21&ndash;25 years age group. Although not statistically significant (<i>P</i>=0.872), a slightly higher proportion of urban residents (95.68%, n = 267) were seropositive compared to rural residents. Furthermore<b>,</b> participants with a history of normal pregnancy (98.59%, n = 166) and those who reported being vaccinated (100%) had a significantly higher seroprevalence of rubella IgG antibodies. </span></span></span><b><span style="font-size:10.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times="">Conclusion:</span></span></span></b> <span lang="EN-IN" style="font-size:10.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times="">This study found a high seroprevalence of rubella IgG antibodies (95.5%) among women of reproductive age in Mysuru, indicating a potentially low risk of rubella infection and a high level of population immunity. This high seroprevalence is likely attributable to the successful implementation of the national Measles-Rubella vaccination campaign</span></span></span> <span lang="EN-IN" style="font-size:10.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times="">in India, as evidenced by the high seroprevalence observed self-reported vaccinated participants</span></span></span><span style="font-size:10.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times="">.</span></span></span> <span style="font-size:10.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times="">Further research is warranted to investigate the duration of rubella immunity conferred by vaccination and to assess the need for booster doses in this population.</span></span></span><br> &nbsp; Rubella, Seroepidemiologic Study, Immunoglobulin G, Pregnancy, Vaccination 270 277 http://jommid.pasteur.ac.ir/browse.php?a_code=A-10-528-1&slc_lang=en&sid=1 Beebi Ameena ameenabeeb27@gmail.com 0009-0009-2869-2559 Yes Department of Microbiology, Mysore Medical College and Research Institute, India Deepa Sriram drdeepadeeps@gmail.com 0000-0003-3121-0660 No Department of Microbiology, Mysore Medical College and Research Institute, India Anuradha Kundapur drkanuradha@yahoo.com 0000-0002-5681-1529 No Mysore Medical College and Research Institute