en Infectious diseases and public health Infectious diseases and public health Review article Review article <span style="line-height:normal"><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">The SARS-COV-2 virus is the cause of the 2020 pandemic that has infected and killed millions worldwide.&nbsp;While the upper respiratory tract cells are the primary targets of COVID-19, the virus can infiltrate other tissues and organs, leading to potentially serious complications. The new coronavirus primarily affects angiotensin II receptor and cytokine pathways, which can result in acute pulmonary inflammation, pulmonary edema, acute respiratory distress syndrome, vascular endothelial dysfunction, pulmonary embolism in the lungs, and cardiomyopathy, arrhythmia, heart failure, and intravenous thrombosis in the heart. COVID-19 infection can be associated with gastrointestinal symptoms such as diarrhea, vomiting, and abdominal pain. Also, reports of mild and transient liver damage, polyneuropathy, encephalitis, stroke, acute renal failure, hypocortisolism, and damage to the hypothalamus and pituitary system are available. COVID-19 can also be associated with skin symptoms such as rash, urticaria, maculopapular lesions, and vascular lesions such as chill blain, petechiae purpura, and scalpopathy. This narrative review evaluates the pathogenesis of novel coronavirus on body organs based on relevant published papers and reference books.</span></span></span><br> <br> &nbsp; COVID-19, Pathogenesis, SARS-COV-2 Infection, Viral infections 1 19 http://jommid.pasteur.ac.ir/browse.php?a_code=A-10-422-1&slc_lang=en&sid=1 Sabereh Ahmadzadeh ahmadzadeh_sa@yahoo.com 0000-0003-4483-005X No School of Pharmacy, Shahid Sadoughi University of Medical science, Yazd, Iran Mehrnoosh Sedighi sedighi.m@lums.ac.ir 0000-0002-2002-2413 No Lorestan University of Medical Sciences, Khorramabad, Iran Amin Torkashvand am1n.torkash7and@yahoo.com 0000-0003-0667-1457 No Malayer Faculty of Nursery, Hamedan University of Medical Sciences and Health Services, Malayer, Hamedan, Iran Pejman Hashemzadeh pejman7genetian@gmail.com 0000-0001-8039-9792 No Department of Medical Biotechnology, Faculty of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran Fateme Shafiei fatemehshafie24@gmail.com No Cardiovascular Research center, Shahid Rahimi Hospital, Lorestan University of Medical Sciences, Khoramabad, Iran Mohammad Torkashvand torkashvand.m@ut.ac.ir 0000-0002-7091-9966 No Fouman Faculty of Engineering, College of Engineering, University of Tehran, Fouman, Iran Atefeh Hasan-Zadeh hasanzadeh.a@ut.ac.ir 0000-0002-4643-4918 Yes Fouman Faculty of Engineering, College of Engineering, University of Tehran, Fouman, Iran