en Host-pathogen interactions and susceptibility factors Host-pathogen interactions and susceptibility factors Review article Review article <span lang="EN-IN" style="font-size:10.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times="">Enteric viruses are the most common cause of gastroenteritis or infectious diarrhea worldwide. The genera <i>Rotavirus</i> (RoV), astrovirus (AstV), and <i>Norovirus</i> (NoV) are predominant viruses causing acute diarrhea in children and inflammation in the gastrointestinal tract. Apart from the enteric viruses, human papillomavirus (HPV), John Cunningham human polyomavirus (JCV), and human immunodeficiency viruses (HIV) are also significantly linked with gastrointestinal inflammation and gastric neoplasia. Moreover, recent studies demonstrated the direct induction of acute gut inflammation by <i>Norovirus</i> infection. Though mild inflammation occurs with astroviral infection, pro-inflammatory signaling pathways are also activated. Epstein-Barr virus (EBV), a significant tumor-causing pathogenic gammaherpesvirus, is also associated with diarrheal disease due to increased local and systemic inflammation. The association of EBV infection with ulcer colitis (UD), Crohn&#39;s disease (CD), inflammatory bowel syndrome (IBD), peptic ulcers, and chronic fatigue syndrome (CFS) indicates its potentiality for enhancing gut inflammation and gastric cancers. In the current scenario, extensive research is a prerequisite to understanding and achieving in-depth knowledge of the molecular mechanisms involved with enteric and tumor viral antigen-induced gut inflammation and cancer progression. This review represents new insights into the current research linking enteric and other pathogenic viruses as a trigger for gut inflammation and gastrointestinal malignancies.&nbsp; </span></span></span> Enteric viruses, Gut infection, Inflammation, Cancer 163 178 http://jommid.pasteur.ac.ir/browse.php?a_code=A-10-404-1&slc_lang=en&sid=1 Roshika Tyagi troshika@gmail.com 0000-0002-6982-197X No Amity Institute of Virology and Immunology (AIVI), J-3 Block, Sector-125, Noida, Amity University, Uttar Pradesh, India; Dept. of Microbiology and Immunology, University of Nevada, Reno, USA Catherine Paul catherinespaul@gmail.com 0000-0002-2280-8591 No Bhaskaracharya College of Applied Sciences, University of Delhi; Department of Microbiology, University of Delhi South Campus, Benito Juarez Road, New Delhi – 110021, India Juni Banerjee chakraborty.juni@gmail.com 0000-0002-3548-4995 No Department of Biotechnology and Bioengineering, Institute of Advanced Research (IAR), Koba institutional area, Gandhinagar, Gujarat- 382426, India Rajeev Kaul rkaul@south.du.ac.in 0000-0003-4455-2723 No Department of Microbiology, University of Delhi South Campus, Benito Juarez Road, New Delhi – 110021, India Shuvomoy Banerjee shuvomoy.banerjee@iar.ac.in 0000-0002-6936-1950 Yes Amity Institute of Virology and Immunology (AIVI), J-3 Block, Sector-125, Noida, Amity University, Uttar Pradesh, India; Department of Biotechnology and Bioengineering, Institute of Advanced Research (IAR), Koba institutional area, Gandhinagar, Gujarat- 382426, India