Journal of Medical Microbiology and Infectious Diseases

en Parameters of Coagulation in COVID-19 Patients: A Correlation with Clinical Severity Diagnostic/screening methods and protocols Diagnostic/screening methods and protocols Original article Original article Introduction: COVID-19 infection can be complicated by coagulation derangement and a high risk of thromboembolic episodes. Our study aimed to investigate coagulation parameters in COVID-19 patients and their correlation with clinical severity. Methods: We analyzed coagulation parameters PT, APTT, D-Dimer, and Fibrinogen in 98 RT-PCR-confirmed COVID-19 patients admitted to the Government Institute of Medical Sciences, Gautam Buddha Nagar, Uttar Pradesh, India. Results: This study involved 69 males (70.50%), and 29 (29.5%) were females. The mortality rate was 6.12% (n= 06). Forty-six patients (46.94%) had comorbidities. Thirty-four patients had elevated PT, and 7 had high APTT, whereas D-dimer and fibrinogen levels were raised in 68 and 61 patients, respectively. Among all four parameters, D-Dimer levels were significantly associated with disease severity. Conclusion: Derangement of D-dimer levels is significantly associated with disease severity in COVID-19 infection. APTT, Coagulation, D-Dimer, Fibrinogen, PT, COVID-19 153 156 http://jommid.pasteur.ac.ir/browse.php?a_code=A-10-403-1&slc_lang=en&sid=1 Shalini Shukla drshalinishukla.8@gmail.com No Government Institute of Medical Sciences, Gautam Buddha Nagar Kanchan Kamini kanchanmbbs@gmail.com No National Institute of Medical Sciences, Jaipur Bhumika Gupta drbhumigupta@gmail.com No Homi Bhabha Cancer Hospital, Varanasi Shalini Bahadur Shalini.bahadur2008@rediffmail.com 0000-0002-9315-5620 No Government Institute of Medical Sciences, Gautam Buddha Nagar Shivani Kalhan shivani.kalhan69@gmail.com 0000-0001-8814-3329 No Government Institute of Medical Sciences, Gautam Buddha Nagar Madhuvan Gupta drmadhuvangupta@gmail.com 0000-0002-7896-7823 Yes Government Institute of Medical Sciences, Gautam Buddha Nagar