en Infectious diseases and public health Infectious diseases and public health Case Report Case Report This study reports an <em>Ophidascaris </em>sp. infection in the gastrointestinal tract of a python snake found at a construction site in Labone, a suburb of Accra and the capital city of Ghana. Examination of the rectal contents of the snake by the zinc sulfate centrifugal floatation method revealed helminths eggs. Besides, examining various sections of the alimentary canal revealed adult worms of the genus <em>Ophidascaris</em> in the anterior half of the small intestine just below the stomach&#39;s pyloric sphincter. Also, milking one of the female worms onto a microscope slide and examining the exudate by microscopy following staining with Lugol&#39;s iodine dye revealed eggs. Our findings may alert the possibility of zoonotic transmission of the parasite from pythons to humans, especially in the suburban/rural areas where people consume snake meat. Python, Ophidascaris, Ghana 103 107 http://jommid.pasteur.ac.ir/browse.php?a_code=A-10-338-2&slc_lang=en&sid=1 Langbong Bimi lbimi@ug.edu.gh 0000-0002-8536-4828 Yes Department of Animal Biology and Conservation Science, University of Ghana, Legon, Accra, Ghana Freda Kailyn Odamtten kayten005@gmail.com 0000-0002-3430-6556 No Department of Animal Biology and Conservation Science, University of Ghana, Legon, Accra, Ghana Francis Anto Fanto@ug.edu.gh 0000-0002-1531-5481 No School of Public Health, University of Ghana, Legon, Accra, Ghana Ato Kwamena Tetteh atetteh3@student.gsu.edu 0000000271615868 No School of Public Health, Georgia State University, Atlanta, Georgia, United States