en Anti-microbial agents, resistance and treatment protocols Anti-microbial agents, resistance and treatment protocols Original article Original article <strong>Introduction: </strong>methicillin-resistant <em>Staphylococcus aureus</em> (MRSA) infection is common among diabetes patients with foot ulcers. This study aimed to determine MRSA isolates prevalence and antibiotic susceptibility profile in diabetic foot ulcers (DFU) patients.<strong> Methods:</strong> A total of 204 patients with diabetic foot ulcers admitted to a tertiary hospital in Abia State, Nigeria, were included in the assay. Specimens were obtained by scraping the ulcer base or the deep portion of the wound edge using a sterile curette and were promptly sent to the laboratory for culture, identification, and antibiotic susceptibility test.&nbsp; <strong>Results:</strong> The MRSA prevalence in DFU patients was 22.1% (n=45). Male patients with DFU were more infected with MRSA (n= 26, 12.7%) than females (n=19, 9.3 %), but the difference was not statistically significant (<em>P</em> < 0.14). The age group 41-60 years had the highest prevalence (n=27, 13.2%), statistically significant (<em>P</em> < 0.02). Farmers had the highest prevalence of 9.8% (n=20) while the least (0.5%) was seen in housewives (n=1) with no statistical significance (<em>P</em> < 0.07). The antibiotics sensitivity pattern of MRSA showed 100% sensitivity to vancomycin and chloramphenicol but 100% resistance to penicillin, ceftriaxone, and oxacillin. The multidrug-resistant index was all > 0.2. <strong>Conclusions:</strong> The prevalence of MRSA in DFU patients in a tertiary hospital in Abia State was very high, with an alarming rate of drug-resistant bacteria due to the possibility of misuse and abuse of antibiotics among the populace, which requires collaborations from all stakeholders to prevent drug resistance in the study settings. Methicillin-resistant staphylococcus aureus, Diabetic foot ulcers, Abia State, Nigeria 71 75 http://jommid.pasteur.ac.ir/browse.php?a_code=A-10-298-2&slc_lang=en&sid=1 Unegbu Valentine N donval4u@yahoo.com 0000-0002-1532-5698 Yes Department of Biological Sciences, Spiritan University Nneochi, Abia State, Nigeria Nwachukwu Ndubuisi O nwachukwundubuisi82@yahoo.com 0000-0002-0329-2374 No Department of Microbiology, Abia State University, Uturu, Abia State, Nigeria Obum-Nnadi Charity N divineportion@gmail.com 0000-0002-4282-5575 No Department of Microbiology, Veritas University Abuja Nigeria. Okey-ndeche Ngozika F ngoziokeyndeche@gmzil.com 0000-0002-7933-9810 No Department of Microbiology, Veritas University Abuja Nigeria