en Infectious diseases and public health Infectious diseases and public health Original article Original article <strong>Introduction</strong>: <em>Salmonella</em> species <em>Salmonella typhi</em> and <em>Salmonella paratyphi</em>, types A, B, and C are the causative agents of enteric fever. This disease continues to pose a severe threat to public health, especially in developing countries. This study investigated the prevalence of typhoidal <em>Salmonella</em> infections and the associated risk factors in Kaduna Metropolis, Nigeria. <strong>Methods</strong>: A questionnaire was used to obtain information from 250 patients attending four selected government hospitals and 50 healthy individuals as control. Blood samples from participants were obtained to determine the blood groups and genotypes, and stool specimens were used to isolate typhoidal <em>Salmonella</em> species. <strong>Results</strong>: Thirty cases were among symptomatic patients and two among controls showing a total prevalence of 10.6%. Among the 32 isolates, 25 were <em>S. typhi</em> (78.1%), and seven were <em>S. paratyphi</em> A (21.9%), revealing an approximate ratio of 4:1. Factors significantly associated with the infection prevalence included age, source of drinking water, and frequency of infection. Blood groups and genotypes were not statistically associated with the infection; however, individuals with blood group O and genotype <em>AA</em> were more commonly infected. Also, females, the age group 20-29, singles, and unemployed, showed more infections. <strong>Conclusion</strong>: The prevalence, the ratio of typhoidal <em>Salmonella</em> species, and the associated risk factors call for public health and control measures, including the provision of suitable drinking water and improving living and sanitary conditions. Typhoidal Salmonella, Enteric fever, Nigeria 84 92 http://jommid.pasteur.ac.ir/browse.php?a_code=A-10-250-3&slc_lang=en&sid=1 Justina Omotola joby4real2link@yahoo.com 0000-0003-3733-9318 Yes Federal University of Agriculture Makurdi Benue Innocent Ogbonna innocentia09@yahoo.com 0000-0003-3428-6177 No Department of Microbiology, College of Science, Federal University of Agriculture, Makurdi, Benue State, Nigeria Charles Iheukwumere ceceiheukwumere@yahoo.com 0000-0002-0803-5676 No Department of Botany, College of Science, Federal University of Agriculture, Makurdi, Benue State, Nigeria