en Microbial pathogenesis Microbial pathogenesis Review article Review article The acute&nbsp;inflammatory response is the body&rsquo;s natural reaction to inciting stimuli including trauma and pathogens. Well-known pro-inflammatory metabolites take control of this reaction to recruit the leukocytes into the inflamed tissue. These cells professionally ingest and kill the invading pathogens and clear the debris of dead or injured cells. This further signals the tissue regeneration and gain of function, another active process mediated by newly uncovered metabolites. These newly identified metabolites are anti-inflammatory in nature and downregulate the active inflammation. These molecules and their cognate receptors are novel targets for the treatment of chronic inflammatory diseases. Although not very well understood, these mediators are suspected to support intracellular parasite survival (as <em>Leishmania</em> parasite) and are worth further investigation for innovative therapeutic interventions. Resolution, lipid mediators, Leishmania infection 61 65 http://jommid.pasteur.ac.ir/browse.php?a_code=A-10-88-2&slc_lang=en&sid=1 Negar Seyed negarse@gmail.com 0000-0001-8249-6692 Yes Department of Immunotherapy and leishmania vaccine research Sima Rafati s_rafati@yahoo.com 0000-0002-7221-1320 No Department of Immunotherapy and Leishmania vaccine research