Volume 14, Issue 1 (3-2026)
JoMMID 2026, 14(1): 17-23 |
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Tina Eghdampanah Foumani 
, Naser Kamyari , Mohammad Mehdi Shadrvan , Fatemeh Khishvand , Fatemeh Shahroud Dezful , Khadijeh Kanani , Atefeh Zahedi , Sara Mobarak , Esmat Radmanesh *
, Naser Kamyari , Mohammad Mehdi Shadrvan , Fatemeh Khishvand , Fatemeh Shahroud Dezful , Khadijeh Kanani , Atefeh Zahedi , Sara Mobarak , Esmat Radmanesh *
Department of Physiology, Abadan University of Medical Sciences (AUMS), Abadan, Iran
Abstract: (735 Views)
Introduction: The interaction between COVID-19 and pre-existing neurological diseases remains poorly understood, highlighting the need to identify key prognostic markers. This study aimed to characterize the clinical and laboratory profiles and identify predictors of peripheral oxygen saturation (SpO₂) in hospitalized patients with pre-existing neurological disorders and COVID-19. Methods: This retrospective observational study included 128 hospitalized patients with pre-existing neurological disorders and confirmed COVID-19 at Taleghani Educational Hospital in Abadan, Iran, from March 2020 to March 2022. Demographic, clinical, and laboratory data were extracted from the Hospital Information System and patient files. Results: On average, patients exhibited elevated levels of key laboratory markers, including renal (creatinine, BUN), hepatic (ALP, direct bilirubin, AST, ALT), coagulation (PT, aPTT, INR), and inflammatory (ESR) markers. The mean peripheral oxygen saturation (SpO₂) was below the normal range (91.71 ± 7.88%). Multivariable linear regression revealed that in-hospital mortality (B = −5.93; P < 0.001), higher respiratory rate (B = −0.10 per breath/min; P = 0.03), and intubation (B = −5.58; P = 0.001) were significantly associated with lower SpO₂ levels. Conclusion: In this cohort of neurological patients with COVID-19, dysregulation of renal, hepatic, and coagulation markers was common. Critically, lower SpO₂ levels were observed in patients with adverse outcomes, including mortality, respiratory distress, and the need for mechanical ventilation. These findings underscore the importance of monitoring these specific biomarkers and SpO₂ to improve risk stratification and guide clinical management in this high-risk patient population.
Keywords: Biomarkers, Coagulation markers, COVID-19, Liver markers, Neurological disorders, Renal markers, SpO₂
Type of Study: Original article |
Subject:
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Received: 2025/07/17 | Accepted: 2026/03/10 | Published: 2026/03/8
Received: 2025/07/17 | Accepted: 2026/03/10 | Published: 2026/03/8
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