en Infectious diseases and public health Infectious diseases and public health Review article Review article <span style="font-size:11pt"><span style="line-height:normal"><span style="text-autospace:none"><span sans-serif="" style="font-family:Calibri,"><b><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">Introduction:</span></span></span></b><i> </i><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">COVID-19 ocular manifestations commonly occur in adults; however, there is limited data on this manifestation in children. This systematic review and meta-analysis investigated the prevalence of ocular manifestations in children.<b> Methods:</b> We searched PubMed, Scopus, EMBASE, Web of Science, and MedRxiv from December 1, 2019, to February 3, 2021. Two independent reviewers screened the articles, extracted the data, and assessed the quality of the articles. </span></span></span><b><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">Results:</span></span></span></b><i> </i><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">After screening 1,510 articles, 19 were approved and included in the systematic review and meta-analysis. The literature review showed that 89 out of 749 children with COVID-19 had at least one ocular manifestation. The estimated pooled prevalence of ocular manifestations was 8.0% (95% confidence intervals 4.0 &ndash; 12.0). The most common symptoms were conjunctival discharge (n = 31, 23.1%), conjunctival congestion (n = 21, 16.0%), eye rubbing (n = 19, 14.2%).</span></span></span><b><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black"> Conclusion:</span></span></span></b><i> </i><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">&nbsp;Ocular manifestations are common in children with COVID-19; one out of 14 infected children shows at least one ocular manifestation. Physicians should pay attention to the ocular manifestations associated with COVID-19 in children.</span></span></span></span></span></span></span> COVID-19, Children, Ocular Manifestations, Conjunctivitis, Systematic Review 58 63 http://jommid.pasteur.ac.ir/browse.php?a_code=A-10-389-1&slc_lang=en&sid=1 Naser Nasiri nasiri.epi@gmail.com 0000-0002-1505-0866 No HIV/STI Surveillance Research Center, and WHO Collaborating Center for HIV Surveillance, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran Hamid Sharifi sharifihami@gmail.com 0000-0002-9008-7618 No HIV/STI Surveillance Research Center, and WHO Collaborating Center for HIV Surveillance, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran Tahereh Rahimi t_rahimi20@yahoo.com 0000-0002-7698-7628 No Department of Public Health, School of Medicine, Jahrom University of Medical Sciences, Jahrom, Iran Ghodsieh Sharif ghodsiehsharif@yahoo.com No Department of Pediatrics, Payambar Azam Hospital, School of Medicine, Islamic Azad University - Kerman Branch, Kerman, Iran Ali Sharifi a_sharifi@kmu.ac.ir 0000-0003-0713-088X Yes Department of Ophthalmology, Shafa Hospital, Afzalipour School of Medicine, Kerman University of Medical Sciences, Kerman, Iran