en Infectious diseases and public health Infectious diseases and public health Case Report Case Report Coronavirus disease (COVID-19) pandemic has affected worldwide health care. Given the possibility for coronavirus to prompt oxidative stress, masked glucose-6-phosphate dehydrogenase deficiency (G6PD) deficiency in the presence of the COVID-19 viral infection may instigate hemolytic crisis and dangerous consequences in affected individuals. G6PD deficiency is an X-linked recessive disorder that affects some 400 million people worldwide, with a higher prevalence in Africa, the Mediterranean Region, and Asia. A dearth of studies and literature on available antivirals for managing COVID-19 patients with G6PD deficiency brings the healthcare workers to a conundrum. Here, we report an interesting symptomatic case of COVID-19 patient with G6PD deficiency, hypertension, and resolved hepatitis B. Antiviral therapy for COVID-19 positive patients with G6PD deficiency should be individualized by considering the risk and benefit of treatment involved, recommending a multidisciplinary team approach. Coronavirus, G6PD deficiency, Hepatitis B, Remdesivir 221 224 http://jommid.pasteur.ac.ir/browse.php?a_code=A-10-344-1&slc_lang=en&sid=1 Prakash Gyandev Gondode drprakash777@gmail.com 0000-0003-1014-8407 Yes Department of Anesthesiology, All India Institute of Medical Sciences, Nagpur, India Ankita Garg ankitagarg12@gmail.com 0000-0001-9256-672X No Department of Anaesthesiology, Dr Babasaheb Ambedkar Hospital, Rohini, Delhi, India Satyajeet Sahoo drsatyajeetsahoo@yahoo.co.in 0000-0003-2996-3305 No Department of Pulmonology, All India Institute of Medical Sciences, Nagpur, India Ankit Sharma drankitsharma91mamc@gmail.com 0000-0003-4743-4028 No Department of Onco-Anesthesia, IRCH, All India Institute of Medical Sciences, Delhi, India