en Infectious diseases and public health Infectious diseases and public health Review article Review article <strong>Introduction: </strong>Despite considerable efforts to control AIDS pandemic, it is still one of the significant infectious concerns worldwide. The advance in medical research has led to the development of highly active antiretroviral therapy with a considerable effect to suppress the disease. However, an effective vaccine capable of eradication the HIV pandemic is not available yet. Failure to develop a prophylactic vaccine diverted the efforts to clinical trials of therapeutic vaccines<em>.</em> <strong>Methods</strong>: Here, we review different approaches to dendritic cell-based HIV therapeutic vaccines. We have summarized the dendritic cell-based trials as HIV therapeutic vaccination, registered in the United States clinical trial database. <strong>Results and</strong> <strong>Conclusion</strong>: The strategies applied in the clinical trials were mostly of low success rates; however, by using dendritic cell therapy, they could trigger the host immune response against HIV-1 infections. Antiretroviral Therapy, Dendritic Cells, HIV-1 89 92 http://jommid.pasteur.ac.ir/browse.php?a_code=A-10-66-1&slc_lang=en&sid=1 Mona Sadat Larijani mona.sadat@gmail.com 0000-0003-3681-5319 No Hepatitis, AIDS and Blood borne diseases Department, Pasteur Institute of Iran, Tehran, Iran Seyed Mehdi Sadat mehdi_sadat@pasteur.ac.ir 0000-0001-7739-179X No Hepatitis, AIDS and Blood borne diseases Department, Pasteur Institute of Iran, Tehran, Iran Azam Bolhassani azam.bolhassani@yahoo.com 0000-0001-7363-7406 No Hepatitis, AIDS and Blood borne diseases Department, Pasteur Institute of Iran, Tehran, Iran Amitis Ramezani amitisramezani@hotmail.com 0000000335028524 Yes Department of Clinical Research, Pasteur Institute of Iran, Tehran, Iran.