Journal of Medical Microbiology and Infectious Diseases
Journal of Medical Microbiology and Infectious Diseases
JoMMID
Medical Sciences
http://jommid.pasteur.ac.ir
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admin
2345-5349
2345-5330
8
10.61882/JoMMID
14
8888
13
en
jalali
1395
10
1
gregorian
2017
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1
5
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online
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fulltext
en
Route of Infection Affects Pathogenicity of Leishmania major in BALB/c Mice
Microbial pathogenesis
Microbial pathogenesis
Original article
Original article
<strong>Introduction: </strong>The term Leishmaniasis applies to a group of parasitic diseases caused by the genus <em>Leishmania</em>. Route of infection is one of the variables that have been reported to influence the immune responses as well as the disease outcome in experimental models of leishmaniasis. This research aims to study the effect of route of infection on the pathogenicity of <em>Leishmania major</em> in BALB/c mice. <strong>Methods:</strong> Low (10<sup>3</sup> parasites/mouse) and high (10<sup>6</sup> parasites/mouse) doses of <em>L. major</em> was injected into footpad or ear dermis of BALB/c mice. Lesion diameter was determined throughout the study. Parasite load of draining lymph nodes and spleen were assessed at three intervals. <strong>Results:</strong> Footpad in comparison to ear route showed higher pathogenicity of <em>L. major</em> in BALB/c mice as assessed by lesion diameter, parasite load in the draining lymph node, and dissemination of the parasite to the spleen. <strong>Conclusion:</strong> Our findings suggest that substantial differences between footpad and ear route need particular attention when we use experimental models for the study of <em>Leishmania</em> infections.
Leishmania major, Pathogenicity, Administration Routes, Viscera, BALB/c mice
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http://jommid.pasteur.ac.ir/browse.php?a_code=A-10-93-1&slc_lang=en&sid=1
Ehsan
Sarreshteh
ehsansarreshteh@yahoo.com