Journal of Medical Microbiology and Infectious Diseases
Journal of Medical Microbiology and Infectious Diseases
JoMMID
Medical Sciences
http://jommid.pasteur.ac.ir
1
admin
2345-5349
2345-5330
8
10.61186/JoMMID
14
8888
13
en
jalali
1395
4
1
gregorian
2016
7
1
4
3
online
1
fulltext
en
Innate Immunity Plays a Key Role in Leishmania Infection: Implications for Vaccine Design
Immune responses, deficiencies and vaccine candidates
Immune responses, deficiencies and vaccine candidates
Review article
Review article
<p dir="ltr"><span style="font-family:garamond,serif;"><span style="font-size:10.0pt;">Neutrophils are part of the first line of immune response and are essential for resistance against a variety of pathogens. They professionally mediate direct killing of pathogens, recruit other phagocytes by specific chemokines, produce cytokines and interact with different immune cells to shape the adaptive response. <em>Leishmania</em> as an obligatory intracellular parasite has evolved to benefit this early innate response to find its way into macrophages, the final host cells. Therefore it is important to reconsider the role of neutrophils for further improvement of the current vaccine status.</span></span></p>
Innate immunity, Neutrophil, Leishmania, Vaccine
39
44
http://jommid.pasteur.ac.ir/browse.php?a_code=A-10-88-1&slc_lang=en&sid=1
Negar
Seyed
negarse@gmail.com
10031947532846001669
10031947532846001669
Yes
Department of Immunotherapy and Leishmania Vaccine Research, Pasteur Institute of Iran, Tehran, Iran
Sima
Rafati
s_rafati@yahoo.com
10031947532846001670
10031947532846001670
No
Department of Immunotherapy and Leishmania Vaccine Research, Pasteur Institute of Iran, Tehran, Iran