en Microbial pathogenesis Microbial pathogenesis Original article Original article <p dir="ltr"><strong><span style="font-family:garamond,serif;"><span style="font-size:10.0pt;">Introduction:</span></span></strong><span style="font-family:garamond,serif;"><span style="font-size:10.0pt;"> The chemistry of metal complexes derived from heterocyclic compounds has attracted considerable interest due to the broad range of pharmacological activities of such compounds. The important pathogens such as <em>Escherichia</em></span></span> <em><span style="font-family:garamond,serif;"><span style="font-size:10.0pt;">coli</span></span></em><span style="font-family:garamond,serif;"><span style="font-size:10.0pt;">, and <em>Staphylococcus aureus</em> are wildly caused many diseases. So antibacterial activity of Zn (</span></span><span style="font-family:batang,serif;"><span style="font-size:10.0pt;">Ⅱ</span></span><span style="font-family:garamond,serif;"><span style="font-size:10.0pt;">), Ni (</span></span><span style="font-family:batang,serif;"><span style="font-size:10.0pt;">Ⅱ</span></span><span style="font-family:garamond,serif;"><span style="font-size:10.0pt;">), Co (</span></span><span style="font-family:batang,serif;"><span style="font-size:10.0pt;">Ⅱ</span></span><span style="font-family:garamond,serif;"><span style="font-size:10.0pt;">) and Cu (</span></span><span style="font-family:batang,serif;"><span style="font-size:10.0pt;">Ⅱ</span></span><span style="font-family:garamond,serif;"><span style="font-size:10.0pt;">) chromone complexes against two kinds of bacteria was established. <strong>Methods:</strong> In this study, antibacterial activity of metal complexes derived from 2-amino-7, 7-dimethyl-5-oxo-4-methylbenzen5, 6, 7, 8-tetra hydro-4H-chromone-3-carbonitrile were studied.&nbsp; The metal complexes were characterized by FTIR, UV-Vis and Mass spectroscopy. Antibacterial effect of these compounds was evaluated by disc diffusion and micro broth dilution methods. <strong>Results</strong>: The results obtained in this study demonstrate that all the complexes have square planner geometry with </span></span><span style="font-family:garamond,serif;"><span style="font-size:10.0pt;">the stoichiometry 1:2 (Metal: Ligand). Among the tested compounds the most effective compound was the Cu complex with MIC value of 62.5 </span></span><span style="font-family:symbol;"><span style="font-size:10.0pt;">m</span></span><span style="font-family:garamond,serif;"><span style="font-size:10.0pt;">g/mL against <em>E. coli</em> and 125 </span></span><span style="font-family:symbol;"><span style="font-size:10.0pt;">m</span></span><span style="font-family:garamond,serif;"><span style="font-size:10.0pt;">g/mL against <em>S. aureus. </em><strong>Conclusion</strong>: </span></span><span style="font-family:garamond,serif;"><span style="font-size:10.0pt;">The results of these studies show that metal the metal complexes had higher antibacterial activity against species when compared to </span></span><span style="font-family:garamond,serif;"><span style="font-size:10.0pt;">parent</span></span><span style="font-family:garamond,serif;"><span style="font-size:10.0pt;"> ligand.</span></span></p> Heterocyclic Compounds, Escherichia coli, Staphylococcus aureus 75 79 http://jommid.pasteur.ac.ir/browse.php?a_code=A-10-115-1&slc_lang=en&sid=1 Hoda Pasdar h_pasdar@iau-tnb.ac.ir Yes islamic azad university, tehran north branch Naser Foroughifar nforoughifar@gmail.com No islamic azad university, tehran north branch Bahare Hedayati Saghavaz bahar.hedayati67@gmail.com No islamic azad university, tehran north branch