AU - Ahmadi Jalali Moghadam, Masoumeh AU - Honarmand, Hamidreza TI - Human Herpesvirus 6 Viremia in Patients with Classic Multiple Scelerosis in Guilan, Iran PT - JOURNAL ARTICLE TA - JoMMID JN - JoMMID VO - 2 VI - 4 IP - 4 4099 - http://jommid.pasteur.ac.ir/article-1-78-en.html 4100 - http://jommid.pasteur.ac.ir/article-1-78-en.pdf SO - JoMMID 4 ABĀ  - Introduction: During the past few years, an increasing body of evidence has suggested a possible role for human herpes virus 6 (HHV-6) in Multiple Sclerosis (MS) pathogenesis. Despite the many reports supporting the relationship between HHV-6 and MS, this association has not been definitely proved or refuted, and the matter remains unresolved. The current study was aimed to investigate any relation between HHV-6 viremia and classic MS in patients in Guilan province, Northern Iran. Method: HHV-6 viremia was certified by molecular detection in study group (n=46) and control group (n=46) using nested-PCR. Data were analyzed by using three statistical tests (Chi square, odd ratio, and Relative Risk). Results: HHV-6 genomic sequences were found totally in 28 out of 46 (60.8%) plasma DNA samples of patients with MS, but were not found in rest of them. It was also found in 13 out of 46 (28.2%) control group. The difference in prevalence of HHV-6 DNA in blood between patients with MS and control group was statistically significant (P=0.0027 and odd ratio=0.277). Conclusion: The data of our study showed that HHV-6 can be implicated in the development of MS. We strongly support the need for further, objective, evidence-based examination of the relationship between HHV-6 infection and MS. CP - IRAN IN - P.O.Box:44145-1533, Lahijan,Iran LG - eng PB - JoMMID PG - 133 PT - Original article YR - 2014