%0 Journal Article %A Ahmadi Jalali Moghadam, Masoumeh %A Honarmand, Hamidreza %T Human Herpesvirus 6 Viremia in Patients with Classic Multiple Scelerosis in Guilan, Iran %J Journal of Medical Microbiology and Infectious Diseases %V 2 %N 4 %U http://jommid.pasteur.ac.ir/article-1-78-en.html %R %D 2014 %K Human Herpes virus 6, Multiple Sclerosis, Nested PCR, Iran, %X Introduction: During the past few years, an increasing body of evidence has suggested a possible role for human herpes virus 6 (HHV-6) in Multiple Sclerosis (MS) pathogenesis. Despite the many reports supporting the relationship between HHV-6 and MS, this association has not been definitely proved or refuted, and the matter remains unresolved. The current study was aimed to investigate any relation between HHV-6 viremia and classic MS in patients in Guilan province, Northern Iran. Method: HHV-6 viremia was certified by molecular detection in study group (n=46) and control group (n=46) using nested-PCR. Data were analyzed by using three statistical tests (Chi square, odd ratio, and Relative Risk). Results: HHV-6 genomic sequences were found totally in 28 out of 46 (60.8%) plasma DNA samples of patients with MS, but were not found in rest of them. It was also found in 13 out of 46 (28.2%) control group. The difference in prevalence of HHV-6 DNA in blood between patients with MS and control group was statistically significant (P=0.0027 and odd ratio=0.277). Conclusion: The data of our study showed that HHV-6 can be implicated in the development of MS. We strongly support the need for further, objective, evidence-based examination of the relationship between HHV-6 infection and MS. %> http://jommid.pasteur.ac.ir/article-1-78-en.pdf %P 133-137 %& 133 %! Human Herpesvirus 6 viremia and MS %9 Original article %L A-10-76-1 %+ Department of Microbiology, Faculty of Medicine, Guilan University of Medical Sciences, Rasht, Iran. %G eng %@ 2345-5349 %[ 2014