Showing 3 results for Taheri
Marziye Taheri, Moein Saleh, Amir Hesam Nemati, Mehdi Ariana, Esfandiar Shojaei, Masoud Mardani, Mohammad Katouli, Mohammad Pooya,
Volume 4, Issue 3 (7-2016)
Abstract
Introduction: Almost 80% of nosocomial urinary tract infections (UTIs) are due to catheterization. Catheter-associated UTI (CAUTI) is the primary source for colonization of antibiotic-resistant pathogens, and uropathogenic Escherichia coli (UPEC) is the most common causative bacteria. This study was conducted to determine the phylogenetic groups, and antibiotic resistance pattern as the two important features of pathogenicity of UPEC isolates collected from urinary catheters. Methods: The UPEC isolates were obtained from the urinary catheters of the patients without UTI, from two referral hospitals during 2015 to 2016. Phylogenetic grouping was performed using a multiplex PCR. Antibiotic susceptibility and extended spectrum beta-lactamase (ESBL) production were tested by the disc diffusion method. Multidrug resistance was determined based on a recent guideline. The presence of some resistance genes was examined by a PCR assay. Results: Thirty-eight percent of the isolates were UPEC, all of them belonged either to B2 (62.5%) or D (37.5%) phylogenetic groups. The UPEC isolates showed a very high resistance to ciprofloxacin (80%) and the third-generation cephalosporins (72.5%). Seventy percent of the isolates were ESBL-producing, and 90% of them were multiple drug resistant (MDR). Meanwhile, the frequency of the resistance genes: ctxM, aacIV, sul1, shv, and qnrA in the isolates were 95%, 82.5%, 77.5%, 72.5%, and 45%, respectively. Conclusion: High resistance to fluoroquinolones and third-generation cephalosporins, as well as high frequency of ESBL-producing and MDR UPEC isolates, are a great concern. This phenomenon is probably the consequence of the indiscriminate use and on the counter availability of antibiotics, which should be considered in empirical therapy of CAUTIs.
Mahsa Golahdooz, Sana Eybpoosh, Rouzbeh Bashar, Mahsa Taherizadeh, Behzad Pourhossein, Mohamadreza Shirzadi, Behzad Amiri, Maryam Fazeli,
Volume 6, Issue 4 (10-2018)
Abstract
Rabies is a zoonotic viral disease. The causative agent is a negative-sense RNA genome virus of the genus Lyssavirus (Family: Rhabdoviridae). The disease, commonly transmitted by rabid dogs, is the cause of mortality of over 59000 humans worldwide annually. This disease can be prevented before the development of symptoms through proper vaccination even after exposure. Hence, improvement of the vaccination schedule in the countries where rabies is endemic is essential. In addition to the type of vaccine, injection routes also contribute to enhanced immune responses and increased potency of the vaccines. The vaccines approved by the World Health Organization (WHO) include cell culture and embryonated egg-based rabies vaccines (CCEEVs). In order to develop a vaccine against rabies, it is necessary to use an appropriate delivery system to promote a proper antigen-specific immune response. Different routes of injection such as intradermal (ID), intramuscular (IM) or subcutaneous (SC) are practiced, with controversies over their suitability. In this article, we discuss the immunological aspects of rabies vaccination by comparing ID and IM delivery systems.
Elaheh Davarpanah, Negar Seyed, Tahereh Taheri,
Volume 13, Issue 1 (3-2025)
Abstract
The development of expression systems using non-pathogenic microorganisms has enabled efficient and safe platforms for medical and food applications, including functional foods with therapeutic benefits. Among non-pathogenic bacteria, Lactococcus lactis (L. lactis) is widely used in biotechnology for various applications, such as vaccine development and protein expression. L. lactis serves as an effective in vivo expression system for developing vaccines and therapeutics in medical research, particularly for parasitic diseases. This review highlights examples of L. lactis-based vaccines for parasitic diseases, demonstrating their ability to elicit protective cellular and humoral immune responses.
