Volume 2, Issue 4 (10-2014)                   JoMMID 2014, 2(4): 133-137 | Back to browse issues page

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Ahmadi Jalali Moghadam M, Honarmand H. Human Herpesvirus 6 Viremia in Patients with Classic Multiple Scelerosis in Guilan, Iran. JoMMID. 2014; 2 (4) :133-137
URL: http://jommid.pasteur.ac.ir/article-1-78-en.html
Department of Microbiology, Faculty of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
Abstract:   (3469 Views)

Introduction: During the past few years, an increasing body of evidence has suggested a possible role for human herpes virus 6 (HHV-6) in Multiple Sclerosis (MS) pathogenesis. Despite the many reports supporting the relationship between HHV-6 and MS, this association has not been definitely proved or refuted, and the matter remains unresolved. The current study was aimed to investigate any relation between HHV-6 viremia and classic MS in patients in Guilan province, Northern Iran. Method: HHV-6 viremia was certified by molecular detection in study group (n=46) and control group (n=46) using nested-PCR. Data were analyzed by using three statistical tests (Chi square, odd ratio, and Relative Risk). Results: HHV-6 genomic sequences were found totally in 28 out of 46 (60.8%) plasma DNA samples of patients with MS, but were not found in rest of them. It was also found in 13 out of 46 (28.2%) control group. The difference in prevalence of HHV-6 DNA in blood between patients with MS and control group was statistically significant (P=0.0027 and odd ratio=0.277). Conclusion: The data of our study showed that HHV-6 can be implicated in the development of MS. We strongly support the need for further, objective, evidence-based examination of the relationship between HHV-6 infection and MS.

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Type of Study: Original article | Subject: Infectious diseases and public health
Received: 2015/12/4 | Accepted: 2016/01/17 | Published: 2016/02/21

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