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:: Volume 2, Issue 4 (10-2014) ::
JoMMID 2014, 2(4): 133-137 Back to browse issues page
Human Herpesvirus 6 Viremia in Patients with Classic Multiple Scelerosis in Guilan, Iran
Masoumeh Ahmadi Jalali Moghadam Mrs., Hamidreza Honarmand Dr.
ph.D Department of Microbiology, Faculty of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
Abstract:   (2327 Views)

Introduction: During the past few years, an increasing body of evidence has suggested a possible role for human herpes virus 6 (HHV-6) in Multiple Sclerosis (MS) pathogenesis. Despite the many reports supporting the relationship between HHV-6 and MS, this association has not been definitely proved or refuted, and the matter remains unresolved. The current study was aimed to investigate any relation between HHV-6 viremia and classic MS in patients in Guilan province, Northern Iran. Method: HHV-6 viremia was certified by molecular detection in study group (n=46) and control group (n=46) using nested-PCR. Data were analyzed by using three statistical tests (Chi square, odd ratio, and Relative Risk). Results: HHV-6 genomic sequences were found totally in 28 out of 46 (60.8%) plasma DNA samples of patients with MS, but were not found in rest of them. It was also found in 13 out of 46 (28.2%) control group. The difference in prevalence of HHV-6 DNA in blood between patients with MS and control group was statistically significant (P=0.0027 and odd ratio=0.277). Conclusion: The data of our study showed that HHV-6 can be implicated in the development of MS. We strongly support the need for further, objective, evidence-based examination of the relationship between HHV-6 infection and MS.

Keywords: Human Herpes virus 6, Multiple Sclerosis, Nested PCR, Iran
Full-Text [PDF 285 kb]   (1212 Downloads)    
Type of Study: Original article | Subject: Infectious diseases and public health
Received: 2015/12/4 | Accepted: 2016/01/17 | Published: 2016/02/21
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Ahmadi Jalali Moghadam M, Honarmand H. Human Herpesvirus 6 Viremia in Patients with Classic Multiple Scelerosis in Guilan, Iran. JoMMID . 2014; 2 (4) :133-137
URL: http://jommid.pasteur.ac.ir/article-1-78-en.html


Volume 2, Issue 4 (10-2014) Back to browse issues page
Journal of Medical Microbiology and Infectious Diseases
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