Department of Cell and Molecular Biology & Microbiology, Faculty of Biological Science and Technology, University of Isfahan, Isfahan, Iran.
Abstract: (9 Views)
Acinetobacter baumannii is a multidrug-resistant, Gram-negative pathogen known for causing severe healthcare-associated infections. This bacterium effectively evades host immune defenses through multiple strategies. It alters surface components like lipopolysaccharides and capsular polysaccharides to avoid recognition by pattern recognition receptors and resist complement activation. A. baumannii also forms biofilms, secretes virulence factors (e.g., proteases, OMVs), and utilizes a type VI secretion system to enhance survival. The pathogen neutralizes reactive oxygen species via antioxidant enzymes and degrades neutrophil extracellular traps to escape immune clearance. It can survive intracellularly in macrophages and modulates inflammasome activation to suppress host responses. Understanding these mechanisms is critical for designing new therapeutics, including vaccines and immunotherapies, to combat this high-priority pathogen.
Keywords: Acinetobacter baumannii, Immune evasion mechanisms, virulence factors, Host Immune Responses, Innate immunity
Type of Study: Review article |
Subject:
Host-pathogen interactions and susceptibility factors
Received: 2025/07/15 | Accepted: 2025/12/10
Received: 2025/07/15 | Accepted: 2025/12/10
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