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Davarpanah E, Seyed N, Taheri T. Lactococcus lactis as a Live-Vector Vaccine Platform for Parasitic Diseases. JoMMID 2025; 13 (1) :16-29
URL: http://jommid.pasteur.ac.ir/article-1-693-en.html
Lactococcus lactis as a Live-Vector Vaccine Platform for Parasitic Diseases
Elaheh Davarpanah , Negar Seyed , Tahereh Taheri *
Department of Immunotherapy and Leishmania Vaccine Research, Pasteur Institute of Iran, Tehran, Iran
Abstract:   (81 Views)
The development of expression systems using non-pathogenic microorganisms has enabled efficient and safe platforms for medical and food applications, including functional foods with therapeutic benefits. Among non-pathogenic bacteria, Lactococcus lactis (L. lactis) is widely used in biotechnology for various applications, such as vaccine development and protein expression. L. lactis serves as an effective in vivo expression system for developing vaccines and therapeutics in medical research, particularly for parasitic diseases. This review highlights examples of L. lactis-based vaccines for parasitic diseases, demonstrating their ability to elicit protective cellular and humoral immune responses.

 
Keywords: Lactococcus lactis, Expression system, Live-vector vaccine, Parasitic diseases, Adjuvant
Full-Text [PDF 948 kb]   (13 Downloads)    
Type of Study: Review article | Subject: Infectious diseases and public health
Received: 2024/11/13 | Accepted: 2025/03/11 | Published: 2025/06/1
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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.