Volume 10, Issue 2 (6-2022)                   JoMMID 2022, 10(2): 58-63 | Back to browse issues page


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Nasiri N, Sharifi H, Rahimi T, Sharif G, Sharifi A. Ocular Manifestations in Children with COVID-19: Systematic Review and Meta-Analysis. JoMMID 2022; 10 (2) :58-63
URL: http://jommid.pasteur.ac.ir/article-1-431-en.html
Department of Ophthalmology, Shafa Hospital, Afzalipour School of Medicine, Kerman University of Medical Sciences, Kerman, Iran
Abstract:   (996 Views)
Introduction: COVID-19 ocular manifestations commonly occur in adults; however, there is limited data on this manifestation in children. This systematic review and meta-analysis investigated the prevalence of ocular manifestations in children. Methods: We searched PubMed, Scopus, EMBASE, Web of Science, and MedRxiv from December 1, 2019, to February 3, 2021. Two independent reviewers screened the articles, extracted the data, and assessed the quality of the articles. Results: After screening 1,510 articles, 19 were approved and included in the systematic review and meta-analysis. The literature review showed that 89 out of 749 children with COVID-19 had at least one ocular manifestation. The estimated pooled prevalence of ocular manifestations was 8.0% (95% confidence intervals 4.0 – 12.0). The most common symptoms were conjunctival discharge (n = 31, 23.1%), conjunctival congestion (n = 21, 16.0%), eye rubbing (n = 19, 14.2%). Conclusion:  Ocular manifestations are common in children with COVID-19; one out of 14 infected children shows at least one ocular manifestation. Physicians should pay attention to the ocular manifestations associated with COVID-19 in children.
Full-Text [PDF 600 kb]   (438 Downloads)    
Type of Study: Review article | Subject: Infectious diseases and public health
Received: 2021/12/10 | Accepted: 2022/06/11 | Published: 2022/06/8

References
1. COVID-19 coronavirus pandemic [Internet]. Worldmeter- real time world statistics; c2021 [cited 23 Apr 2021]; Available from: https://www.worldometers.info/coronavirus/.
2. Lee P-I, Hu Y-L, Chen P-Y, Huang Y-C, Hsueh P-R. Are children less susceptible to COVID-19? J Microbiol Immunol Infect. 2020; 53 (3): 371-2. [DOI:10.1016/j.jmii.2020.02.011]
3. COVID-19 and Children [Internet]. WHO; c2021 [cited 9 Apr 2021]; Available;https://www.euro.who.int/en/health-topics/Life-stages/child-and-adolescent-health/covid-19-and-children/.
4. Viner RM, Mytton OT, Bonell C, Melendez-Torres G, Ward J, Hudson L, et al. Susceptibility to SARS-CoV-2 infection among children and adolescents compared with adults: a systematic review and meta-analysis. JAMA Pediatr. 2021; 175 (2): 143-56. [DOI:10.1001/jamapediatrics.2020.4573]
5. Seah I, Agrawal R. Can the coronavirus disease 2019 (COVID-19) affect the eyes? A review of coronaviruses and ocular implications in humans and animals. Ocul Immunol Inflamm. 2020; 28 (3): 391-5. [DOI:10.1080/09273948.2020.1738501]
6. Seah IYJ, Anderson DE, Kang AEZ, Wang L, Rao P, Young BE, et al. Assessing viral shedding and infectivity of tears in coronavirus disease 2019 (COVID-19) patients. Ophthalmol. 2020; 127 (7): 977-9. [DOI:10.1016/j.ophtha.2020.03.026]
7. Valente P, Iarossi G, Federici M, Petroni S, Palma P, Cotugno N, et al. Ocular manifestations and viral shedding in tears of pediatric patients with coronavirus disease 2019: a preliminary report. J AAPOS. 2020; 24 (4): 212-5. [DOI:10.1016/j.jaapos.2020.05.002]
8. Ma N, Li P, Wang X, Yu Y, Tan X, Chen P, et al. Ocular manifestations and clinical characteristics of children with laboratory-confirmed COVID-19 in Wuhan, China. JAMA Ophthalmol. 2020; 138 (10): 1079-86. [DOI:10.1001/jamaophthalmol.2020.3690]
9. Pousa PA, de Mendonca TS, Oliveira EA, e Silva ACS. Extrapulmonary manifestations of COVID-19 in children: a comprehensive review and pathophysiological considerations. J Pediatr (Rio J). 2021; 97 (2): 116-39. [DOI:10.1016/j.jped.2020.08.007]
10. Zhong Y, Wang K, Zhu Y, Lyu D, Yao K. COVID-19 and the Eye. J Infect. 2020; 81 (2):e122-e123 . [DOI:10.1016/j.jinf.2020.05.054]
11. Nasiri N, Sharifi H, Bazrafshan A, Noori A, Karamouzian M, Sharifi A. Ocular manifestations of COVID-19: a systematic review and meta-analysis. J Ophthalmic Vis Res. 2021; 16 (1): 103-12. [DOI:10.18502/jovr.v16i1.8256]
12. Al-Namaeh M. COVID-19 in the light of current clinical eye research. Eur J Ophthalmol. 2021; 31 (3): 904-8. [DOI:10.1177/1120672121998911]
13. Quaranta L, Rovida F, Riva I, Bruttini C, Brambilla I, Baldanti F, et al. Identification of SARS-CoV-2 RNA in the conjunctival swab of an Italian pediatric patient affected with COVID-19: A case report. Eur J Ophthalmol. 2020 December 2: 1120672120977822. [DOI:10.1177/1120672120977822]
14. Alnashri H, Aljohani N, Tayeb S, Rabie N, AlBenayan E, Alharthi A, et al. A challenging case of multisystem inflammatory syndrome in children related to coronavirus Disease-19 hospitalized under adult medical service. IDCases. 2020; 22: e00957. [DOI:10.1016/j.idcr.2020.e00957]
15. Rayamajhi A, Sharma M, Deo MK, Shrestha S, Bista KP, Paudel KP. Kawasaki Disease like Multisystem Inflammatory Syndrome in a Toddler during SARS-CoV-2 Pandemic in Nepal. J Nepal Health Res Counc. 2021; 18 (4): 789-91. [DOI:10.33314/jnhrc.v18i4.3281]
16. Sanaei Dashti A, Mehdipour Namdar Z. Ocular Complication of a Child with Confirmed 2019 Novel Coronavirus Disease: A Case Report. Arch Pediatr Infect Dis. 2021; doi: 10.5812/pedinfect.109981. [DOI:10.5812/pedinfect.109981]
17. Abbas M, Törnhage C-J. Family Transmission of COVID-19 Including a Child with MIS-C and Acute Pancreatitis. Int Med Case Rep J. 2021; 14: 55-65. [DOI:10.2147/IMCRJ.S284480]
18. de Oliveira MR, Lucena ARV, Higino TM, Ventura CV. Oculomotor nerve palsy in an asymptomatic child with COVID-19. J AAPOS. 2021; 25 (3): 169-70. [DOI:10.1016/j.jaapos.2021.02.001]
19. Storch-de-Gracia P, Leoz-Gordillo I, Andina D, Flores P, Villalobos E, Escalada-Pellitero S, et al. Clinical spectrum and risk factors for complicated disease course in children admitted with SARS-CoV-2 infection. An Pediatr (Engl Ed). 2020; 93 (5): 323-33. [DOI:10.1016/j.anpedi.2020.07.025]
20. Alcalde CF, Fernandez MG, Moreno MN, Martin SN. COVID-19 ocular findings in paediatric population. 2020. [DOI:10.21203/rs.3.rs-102973/v1]
21. Kumar K, Prakash AA, Gangasagara SB, Rathod SB, Ravi K, Rangaiah A, et al. Presence of viral RNA of SARS-CoV-2 in conjunctival swab specimens of COVID-19 patients. Indian J Ophthalmol. 2020; 68 (6): 1015-17. [DOI:10.4103/ijo.IJO_1287_20]
22. Perez-Chimal LG, Cuevas GG, Di-Luciano A, Chamartin P, Amadeo G, Martinez-Castellanos MA. Ophthalmic manifestations associated with SARS-CoV-2 in newborn infants: a preliminary report. J AAPOS. 2021; 25 (2): 102-4. [DOI:10.1016/j.jaapos.2020.11.007]
23. Borgi A, Khadhraoui H, Louati A, Ayari A, Hajji A, Bouziri A, et al. First Tunisian cluster admissions of critically ill patients with multisystem inflammatory syndrome in children (MIS-C). Mediterr J Hematol Infect Dis. 2020; 13 (1): e2021023. [DOI:10.4084/mjhid.2021.023]
24. Shobhavat L, Solomon R, Rao S, Bhagat I, Prabhu S, Prabhu S, et al. Multisystem Inflammatory Syndrome in Children: Clinical Features and Management-Intensive Care Experience from a Pediatric Public Hospital in Western India. Indian J Crit Care Med. 2020; 24 (11): 1089-94. [DOI:10.5005/jp-journals-10071-23658]
25. Guo C-X, He L, Yin J-Y, Meng X-G, Tan W, Yang G-P, et al. Epidemiological and clinical features of pediatric COVID-19. BMC Med. 2020; 18 (1): 250. [DOI:10.1186/s12916-020-01719-2]
26. Mamishi S, Heydari H, Aziz-Ahari A, Shokrollahi MR, Pourakbari B, Mahmoudi S, et al. Novel coronavirus disease 2019 (COVID-19) outbreak in children in Iran: atypical CT manifestations and mortality risk of severe COVID-19 infection. J Microbiol Immunol Infect. 2021; 54 (5): 839-44. [DOI:10.1016/j.jmii.2020.07.019]
27. Al Yazidi L, Al Hinai Z, Al Waili B, Al Hashemi H, Al Reesi M, Al Othmani F, et al. Epidemiology, characteristics, and outcomes of hospitalized children with COVID-19 in Oman: A multicenter cohort study. Int J Infect Dis. 2021; 104: 655-60. [DOI:10.1016/j.ijid.2021.01.036]
28. Freeman MC, Gaietto K, DiCicco LA, Rauenswinter S, Squire JR, Aldewereld Z, et al. A Comprehensive Clinical Description of Pediatric SARS-CoV-2 Infection in Western Pennsylvania. medRxiv 2020. December 16. [DOI:10.1101/2020.12.14.20248192]
29. Andina-Martinez D, Nieto-Moro M, Alonso-Cadenas JA, Añon-Hidalgo J, Hernandez-Martin A, Perez-Suarez E, et al. Mucocutaneous manifestations in children hospitalized with COVID-19. J Am Acad Dermatol. 2021: S0190-9622(21)00646-0.
30. Aggarwal K, Agarwal A, Jaiswal N, Dahiya N, Ahuja A, Mahajan S, et al. Ocular surface manifestations of coronavirus disease 2019 (COVID-19): A systematic review and meta-analysis. PLoS One. 2020; 15 (11): e0241661. [DOI:10.1371/journal.pone.0241661]
31. Sindhuja K, Lomi N, Asif MI, Tandon R. Clinical profile and prevalence of conjunctivitis in mild COVID-19 patients in a tertiary care COVID-19 hospital: A retrospective cross-sectional study. Indian J Ophthalmol. 2020; 68 (8): 1546-50. [DOI:10.4103/ijo.IJO_1319_20]
32. Wu P, Liang L, Chen C, Nie S. A child confirmed COVID-19 with only symptoms of conjunctivitis and eyelid dermatitis. Graefes Arch Clin Exp Ophthalmol. 2020; 258 (7): 1565-66. [DOI:10.1007/s00417-020-04708-6]
33. Arias-Peso B, Rendón-Fernández H. Conjunctivitis and COVID-19: The importance of an early detection. Enferm Infecc Microbiol Clin. 2021; 39 (2): 111. [DOI:10.1016/j.eimc.2020.07.004]

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Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.