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:: Volume 4, Number 1 and 2 (1-2016) ::
JoMMID 2016, 4(1 and 2): 1-7 Back to browse issues page
HSP Roles as Biomarkers and Antigens in Bacterial and Viral Infections
Alireza Milani, Marzieh Basirnejad, Sepideh Shahbazi, Azam Bolhassani
PhD Department of Hepatitis and AIDS, Pasteur Institute of Iran, Tehran, Iran
Abstract:   (521 Views)

Diagnosis of infectious diseases remains an important issue in medical science. Identification of biomarkers can be used to predict early infections. Recently, heat shock proteins (HSPs) have been known as the conserved compounds expressed under stress conditions in both prokaryotic and eukaryotic systems. These proteins act as molecular chaperones. Several studies showed the increased levels of HSPs in patients suffering from infectious diseases suggesting the role of HSPs as promising biomarkers. Also, Hsps possess significant roles in antigen presentation, the maturation of dendritic cells and the activation of lymphocytes. Thus, these proteins can be utilized to develop vaccines in bacterial and viral infections. In this mini-review, we will briefly describe the important roles of HSPs in diagnosis and immunity in bacterial and viral infections.

Keywords: Heat shock protein, Infection, Biomarker, Immunity
Full-Text [PDF 406 kb]   (259 Downloads)    
Type of Study: Mini Review | Subject: Immune responses, deficiencies and vaccine candidates
Received: 2017/04/24 | Accepted: 2017/04/29 | Published: 2017/06/3
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Milani A, Basirnejad M, Shahbazi S, Bolhassani A. HSP Roles as Biomarkers and Antigens in Bacterial and Viral Infections . JoMMID . 2016; 4 (1 and 2) :1-7
URL: http://jommid.pasteur.ac.ir/article-1-119-en.html
Volume 4, Number 1 and 2 (1-2016) Back to browse issues page
Journal of Medical Microbiology and Infectious Diseases
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