:: Main :: About :: Current Articles :: Archive :: Article In Press :: Submit manuscript :: Contact ::
:: Volume 3, Number 3 and 4 (7-2015) ::
JoMMID 2015, 3(3 and 4): 44-47 Back to browse issues page
Molecular Epidemiology of HIV-1 in Afghanistan, Iran, and Pakistan
Fatemeh Jahanbakhsh, Sana Eybpoosh, Ehsan Mostafavi, AliAkbar Haghdoost, Kayhan Azadmanesh
Ph.D Virology Research Group, Pasteur Institute of Iran, Tehran, Iran
Abstract:   (1140 Views)

We conducted this study to obtain a comprehensive picture of molecular epidemiology of HIV-1 in three neighboring countries, i.e. Afghanistan, Iran, and Pakistan as a basis for discussing possible hypothesis regarding between-country virus transmission. Our results showed that subtype composition differs between these countries with more variation in Pakistan than Iran and Afghanistan. The CRF35-AD clade was predominant in Afghanistan and Iran while the A1 subtype was predominant in Pakistan. HIV-1 sequences obtained from Pakistan (belonging either to B, A1, or CRF35_AD clades)  did not group with the sequences obtained from Afghanistan and Iran. However, CRF35_AD clades from Afghanistan made two significant clusters with those strains from Iran. The results also showed that CRF35_AD clades from Afghanistan had more diversity than those in Iran suggesting its older presence in this country. Putting these findings together and considering drug trafficking/immigration events from Afghanistan to Iran we hypothesized that HIV epidemics might have been transmitted from Iran to Afghanistan. However, the reverse order might also be true but with less support from the existing evidence. There was no indication of Iran-Pakistan HIV transmission. Performing sophisticated evolutionary analysis is needed to test these hypotheses about the origin and transmission pattern of the virus among these countries.

Keywords: Molecular Epidemiology, HIV-I, Afghanistan, Iran, Pakistan
Full-Text [PDF 412 kb]   (389 Downloads)    
Type of Study: Short communication | Subject: Epidemiologic studies including microbial genotyping, phenotyping and serotyping
Received: 2017/03/6 | Accepted: 2017/03/11 | Published: 2017/03/17
Send email to the article author

Add your comments about this article
Your username or email:

Write the security code in the box >



XML     Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Jahanbakhsh F, Eybpoosh S, Mostafavi E, Haghdoost A, Azadmanesh K. Molecular Epidemiology of HIV-1 in Afghanistan, Iran, and Pakistan . JoMMID . 2015; 3 (3 and 4) :44-47
URL: http://jommid.pasteur.ac.ir/article-1-117-en.html
Volume 3, Number 3 and 4 (7-2015) Back to browse issues page
Journal of Medical Microbiology and Infectious Diseases
Persian site map - English site map - Created in 0.175 seconds with 842 queries by yektaweb 3501