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:: Volume 3, Number 3 and 4 (7-2015) ::
JoMMID 2015, 3(3 and 4): 75-79 Back to browse issues page
Investigation into the Antibacterial Activity of Metal Complexes Derived from Substituted Chromone in Comparison with Tetracycline, and Cephradine as Standard Drugs against Escherichia coli and Staphylococcus aureus
Hoda Pasdar , Naser Foroughifar, Bahare Hedayati Saghavaz
Ph.D islamic azad university, tehran north branch
Abstract:   (604 Views)

Introduction: The chemistry of metal complexes derived from heterocyclic compounds has attracted considerable interest due to the broad range of pharmacological activities of such compounds. The important pathogens such as Escherichia coli, and Staphylococcus aureus are wildly caused many diseases. So antibacterial activity of Zn (), Ni (), Co () and Cu () chromone complexes against two kinds of bacteria was established. Methods: In this study, antibacterial activity of metal complexes derived from 2-amino-7, 7-dimethyl-5-oxo-4-methylbenzen5, 6, 7, 8-tetra hydro-4H-chromone-3-carbonitrile were studied.  The metal complexes were characterized by FTIR, UV-Vis and Mass spectroscopy. Antibacterial effect of these compounds was evaluated by disc diffusion and micro broth dilution methods. Results: The results obtained in this study demonstrate that all the complexes have square planner geometry with the stoichiometry 1:2 (Metal: Ligand). Among the tested compounds the most effective compound was the Cu complex with MIC value of 62.5 mg/mL against E. coli and 125 mg/mL against S. aureus. Conclusion: The results of these studies show that metal the metal complexes had higher antibacterial activity against species when compared to parent ligand.

Keywords: Heterocyclic Compounds, Escherichia coli, Staphylococcus aureus
Full-Text [PDF 739 kb]   (257 Downloads)    
Type of Study: Original article | Subject: Microbial pathogenesis
Received: 2016/12/16 | Accepted: 2017/05/3 | Published: 2017/05/22
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Pasdar H, Foroughifar N, Hedayati Saghavaz B. Investigation into the Antibacterial Activity of Metal Complexes Derived from Substituted Chromone in Comparison with Tetracycline, and Cephradine as Standard Drugs against Escherichia coli and Staphylococcus aureus. JoMMID . 2015; 3 (3 and 4) :75-79
URL: http://jommid.pasteur.ac.ir/article-1-111-en.html
Volume 3, Number 3 and 4 (7-2015) Back to browse issues page
Journal of Medical Microbiology and Infectious Diseases
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